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Akinobu Gotoh
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Journal Articles

Adenosine Deaminase Inhibitor EHNA Exhibits a Potent Anticancer Effect Against Malignant Pleural Mesothelioma

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Yasuhiro Nakajima, Takeshi Kanno, Toshio Nagaya, Kozo Kuribayashi, Takashi Nakano, Akinobu Gotoh, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2015) 35 (1): 51–60.
https://doi.org/10.1159/000369674
Published Online: 02 January 2015
View articletitled, Adenosine Deaminase Inhibitor EHNA Exhibits a Potent Anticancer Effect Against Malignant Pleural Mesothelioma
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Journal Articles

Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor

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Emma Tabe Eko Niba, Hisao Nagaya, Takeshi Kanno, Ayako Tsuchiya, Akinobu Gotoh, Chiharu Tabata, Kohzo Kuribayashi, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2013) 31 (6): 905–913.
https://doi.org/10.1159/000350108
Published Online: 17 June 2013
View articletitled, Crosstalk between PI3 Kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK Pathways Downstream PDGF Receptor
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Journal Articles

A 3 Adenosine Receptor Mediates Apoptosis in 5637 Human Bladder Cancer Cells by G q Protein/PKC-Dependent AIF Upregulation

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Takeshi Kanno, Akinobu Gotoh, Yumiko Fujita, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (5): 1159–1168.
https://doi.org/10.1159/000343306
Published Online: 05 October 2012
View articletitled, A 3 Adenosine Receptor Mediates Apoptosis in 5637 Human Bladder Cancer Cells by G q Protein/PKC-Dependent AIF Upregulation
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Journal Articles

Sphingosine Induces Apoptosis in MKN-28 Human Gastric Cancer Cells in an SDK-Dependent Manner

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Takeshi Kanno, Takaaki Nishimoto, Yumiko Fujita, Akinobu Gotoh, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (4): 987–994.
https://doi.org/10.1159/000341475
Published Online: 20 September 2012
View articletitled, Sphingosine Induces Apoptosis in MKN-28 Human Gastric Cancer Cells in an SDK-Dependent Manner
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Journal Articles

Sphingosine Suppresses Mesothelioma Cell Proliferation by Inhibiting PKC-δ and Inducing Cell Cycle Arrest at the G₀/G 1 Phase

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Hisaya Okuwa, Takeshi Kanno, Yumiko Fujita, Akinobu Gotoh, Chiharu Tabata, Kazuya Fukuoka, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (4): 995–1004.
https://doi.org/10.1159/000341476
Published Online: 20 September 2012
View articletitled, Sphingosine Suppresses Mesothelioma Cell Proliferation by Inhibiting PKC-δ and Inducing Cell Cycle Arrest at the G₀/G 1 Phase
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Journal Articles

Adenosine Induces Apoptosis in SBC-3 Human Lung Cancer Cells through A 3 Adenosine Receptor-Dependent AMID Upregulation

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Takeshi Kanno, Takashi Nakano, Yumiko Fujita, Akinobu Gotoh, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (3): 666–677.
https://doi.org/10.1159/000341447
Published Online: 31 July 2012
View articletitled, Adenosine Induces Apoptosis in SBC-3 Human Lung Cancer Cells through A 3 Adenosine Receptor-Dependent AMID Upregulation
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Journal Articles

A 3 Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells

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Tai-ichiro Otsuki, Takeshi Kanno, Yumiko Fujita, Chiharu Tabata, Kazuya Fukuoka, Takashi Nakano, Akinobu Gotoh, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (1): 210–220.
https://doi.org/10.1159/000339058
Published Online: 19 June 2012
View articletitled, A 3 Adenosine Receptor-Mediated p53-Dependent Apoptosis in Lu-65 Human Lung Cancer Cells
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Journal Articles

AMP Converted from Intracellularly Transported Adenosine Upregulates p53 Expression to Induce Malignant Pleural Mesothelioma Cell Apoptosis

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Yoshitaka Nogi, Takeshi Kanno, Takashi Nakano, Yumiko Fujita, Chiharu Tabata, Kazuya Fukuoka, Akinobu Gotoh, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 30 (1): 61–74.
https://doi.org/10.1159/000339048
Published Online: 08 June 2012
View articletitled, AMP Converted from Intracellularly Transported Adenosine Upregulates p53 Expression to Induce Malignant Pleural Mesothelioma Cell Apoptosis
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Journal Articles

Mesothelioma Cell Proliferation through Autocrine Activation of PDGF- ββ Receptor

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Miki Honda, Takeshi Kanno, Yumiko Fujita, Akinobu Gotoh, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 29 (5-6): 667–674.
https://doi.org/10.1159/000176386
Published Online: 11 May 2012
View articletitled, Mesothelioma Cell Proliferation through Autocrine Activation of PDGF- ββ Receptor
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Journal Articles

Apoptosis-Related Gene Transcription in Human A549 Lung Cancer Cells via A 3 Adenosine Receptor

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Hitomi Kamiya, Takeshi Kanno, Yumiko Fujita, Akinobu Gotoh, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 29 (5-6): 687–696.
https://doi.org/10.1159/000312589
Published Online: 11 May 2012
View articletitled, Apoptosis-Related Gene Transcription in Human A549 Lung Cancer Cells via A 3 Adenosine Receptor
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Journal Articles

PDGF-D/PDGF-ββ Receptor-Regulated Chemo-taxis of Malignant Mesothelioma Cells

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Asuka Okada, Takahiro Yaguchi, Takeshi Kanno, Akinobu Gotoh, Takashi Nakano, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2012) 29 (1-2): 241–250.
https://doi.org/10.1159/000337605
Published Online: 01 March 2012
View articletitled, PDGF-D/PDGF-ββ Receptor-Regulated Chemo-taxis of Malignant Mesothelioma Cells
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Journal Articles

Adenosine Promotes GATA-2-Regulated p53 Gene Transcription to Induce HepG2 Cell Apoptosis

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Takahiro Yaguchi, Takashi Nakano, Akinobu Gotoh, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2011) 28 (4): 761–770.
https://doi.org/10.1159/000335770
Published Online: 14 December 2011
View articletitled, Adenosine Promotes GATA-2-Regulated p53 Gene Transcription to Induce HepG2 Cell Apoptosis
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Journal Articles

AMID Mediates Adenosine-Induced Caspase-Independent HuH-7 Cell Apoptosis

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Dongqin Yang, Takahiro Yaguchi, Tetsu Nagata, Akinobu Gotoh, Sinisa Dovat, Chunhua Song, Tomoyuki Nishizaki
Journal: Cellular Physiology and Biochemistry
Cellular Physiology and Biochemistry (2011) 27 (1): 37–44.
https://doi.org/10.1159/000325203
Published Online: 11 February 2011
View articletitled, AMID Mediates Adenosine-Induced Caspase-Independent HuH-7 Cell Apoptosis
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