Background: Prognostic factor research methodology has not yet been applied to randomized clinical trial data of homeopathic medicines. Objectives: To investigate the principle of individualization in homeopathy by developing a prognostic factor prediction model. Method: A pooled, in-dividual patient data meta-analysis of 3 randomized trials -investigating the efficacy of a homeopathic gel (Spiroflor SRL®) containing Rhus toxicodendron as a key ingredient in osteoarthritis of the knee and acute low back pain. The prognostic value of a predefined set of 5 typical R. toxicodendron symptoms was investigated by assessing treatment-by-symptom interactions on pain as an outcome measure in a regression model. Results: The pooled dataset consisted of 284 patients in the Spiroflor SRL group and 275 patients in the control group. Adjusted for pain at baseline, a statistically significant effect modification for the symptoms “numbness or tingling of the affected part” (+2.0 mm VAS; p = 0.02), “amelioration by movement” (–5.6 mm VAS; p = 0.01), and “amelioration of pain by local heat” (+7.0 mm VAS; p = 0.02) was found. Conclusions: Investigating aspects of treatment individualization in homeopathy using randomized trial data and standard meta-analytical techniques is possible. The symptom amelioration by local heat is of possible value as a homeopathic symptom (prognostic factor) predicting an increased likelihood of pain relief following treatment with the homeopathic product.

Keywords:
Prognostic factor research, Individual patient data meta-analysis, Treatment individualization, Spiroflor SRL® gel
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The Author(s). Published by S. Karger AG, Basel
2020
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