Abstract
Objective: We evaluated the efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. Methods: A total of 264 patients aged 22–40 years were enrolled, who received carboprost tromethamine and suffered nausea and vomiting during cesarean section under lumbar anesthesia. The patients were divided randomly into the control group, electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group. Results: Compared to the control group, the nausea and vomiting scores decreased at T3 in both the electroacupuncture and electroacupuncture + tropisetron groups, and decreased at T4 in the electroacupuncture group, tropisetron group, and electroacupuncture + tropisetron group; the motilin, gastrin, and 5-hydroxytryptamine (5-HT) levels decreased at T5 in the other 3 groups. Compared to the electroacupuncture + tropisetron group, the nausea and vomiting scores increased at T3 in the control and tropisetron groups, and increased at T4 in the other 3 groups; the motilin, gastrin, and 5-HT levels increased at T5. Conclusions: Our study suggested that electroacupuncture combined with tropisetron could effectively relieve carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. The effect was better than its single application, and the reduced 5-HT, motilin, and gastrin levels might be involved in the underlying mechanism.
References
1.
Bai
J
, Sun
Q
, Zhai
H
. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery
. Exp Ther Med
. 2014
Jan
;7
(1
):46
–50
.
[PubMed]
1792-09812.
Priya
GP
, Veena
P
, Chaturvedula
L
, Subitha
L
. A randomized controlled trial of sublingual misoprostol and intramuscular oxytocin for prevention of postpartum hemorrhage
. Arch Gynecol Obstet
. 2015
Dec
;292
(6
):1231
–7
.
[PubMed]
0932-00673.
Hu
J
, Yu
ZP
, Wang
P
, Shi
CY
, Yang
HX
. Clinical Analysis of Postpartum Hemorrhage Requiring Massive Transfusions at a Tertiary Center
. Chin Med J (Engl)
. 2017
Mar
;130
(5
):581
–5
.
[PubMed]
0366-69994.
Zhang
R
, Shi
H
, Ren
F
, Yuan
Z
. Assessment of carboprost tromethamine for reducing hemorrhage in laparoscopic intramural myomectomy
. Exp Ther Med
. 2015
Sep
;10
(3
):1171
–4
.
[PubMed]
1792-09815.
Chu
KO
, Wang
CC
, Pang
CP
, Rogers
MS
. Method to determine stability and recovery of carboprost and misoprostol in infusion preparations
. J Chromatogr B Analyt Technol Biomed Life Sci
. 2007
Sep
;857
(1
):83
–91
.
[PubMed]
1570-02326.
Barney
OJ
, Haughney
RV
, Bilolikar
A
. A case of pulmonary oedema secondary to carboprost.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2012
; 32: 597-599. 7.
Jin
S
, Liang
DD
, Chen
C
, Zhang
M
, Wang
J
. Dexmedetomidine prevent postoperative nausea and vomiting on patients during general anesthesia: A PRISMA-compliant meta analysis of randomized controlled trials
. Medicine (Baltimore)
. 2017
Jan
;96
(1
):e5770
.
[PubMed]
0025-79748.
Wesmiller
SW
, Sereika
SM
, Bender
CM
, Bovbjerg
D
, Ahrendt
G
, Bonaventura
M
, et al Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer
. Auton Neurosci
. 2017
Jan
;202
:102
–7
.
[PubMed]
1566-07029.
Xiong
L
, Lu
Z
, Hou
L
, Zheng
H
, Zhu
Z
, Wang
Q
, et al Pretreatment with repeated electroacupuncture attenuates transient focal cerebral ischemic injury in rats
. Chin Med J (Engl)
. 2003
Jan
;116
(1
):108
–11
.
[PubMed]
0366-699910.
Zheng
H
, Li
Y
, Zhang
W
, Zeng
F
, Zhou
SY
, Zheng
HB
, et al Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial
. Medicine (Baltimore)
. 2016
Jun
;95
(24
):e3884
.
[PubMed]
0025-797411.
Zhang
X
, Fan
YH
. [Effects of electroacupuncture on chemotherapy-induced nausea and vomiting and its mechanism]
. Zhongguo Zhen Jiu
. 2014
Nov
;34
(11
):1061
–4
.
[PubMed]
0255-293012.
Zhang
X
, Jin
HF
, Fan
YH
, et al Effects and mechanisms of transcutaneous electroacupuncture on chemotherapy-induced nausea and vomiting.
Evidence-based complementary and alternative medicine : eCAM 2014; 2014
: 860631. 13.
Chen
B
, Hu
SX
, Liu
BH
, Zhao
TY
, Li
B
, Liu
Y
, et al Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial
. Trials
. 2015
May
;16
(1
):212
.
[PubMed]
1745-621514.
Bunce
KT
, Tyers
MB
. The role of 5-HT in postoperative nausea and vomiting
. Br J Anaesth
. 1992
;69
(7
Suppl 1
):60S
–2S
.
[PubMed]
0007-091215.
Chepyala
P
, Olden
KW
. Nausea and vomiting
. Curr Treat Options Gastroenterol
. 2008
Apr
;11
(2
):135
–44
.
[PubMed]
1092-847216.
Sanger
GJ
, Broad
J
, Andrews
PL
. The relationship between gastric motility and nausea: gastric prokinetic agents as treatments
. Eur J Pharmacol
. 2013
Sep
;715
(1-3
):10
–4
.
[PubMed]
0014-299917.
Yang
Y
, Zhang
Y
, Jing
NC
, Lu
Y
, Xiao
HY
, Xu
GL
, et al [Electroacupuncture at Zusanli (ST 36) for treatment of nausea and vomiting caused by the chemotherapy of the malignant tumor: a multicentral randomized controlled trial]
. Zhongguo Zhen Jiu
. 2009
Dec
;29
(12
):955
–8
.
[PubMed]
0255-293018.
Manullang
TR
, Viscomi
CM
, Pace
NL
. Intrathecal fentanyl is superior to intravenous ondansetron for the prevention of perioperative nausea during cesarean delivery with spinal anesthesia
. Anesth Analg
. 2000
May
;90
(5
):1162
–6
.
[PubMed]
0003-299919.
Chatterjee
S
, Bisui
B
, Mandal
A
, Sheet
J
, Sengupta
S
, Majumdar
S
, et al Effects of intrathecal hyperbaric ropivacaine versus hyperbaric bupivacaine for lower limb orthopedic surgery
. Anesth Essays Res
. 2014
Sep-Dec
;8
(3
):349
–53
.
[PubMed]
0259-116220.
Wei
X
, Yao
SL
, Zhang
XM
. Comparison of different methods of administering tropisetron in patient-controlled analgesia in the prevention of postoperative nausea and vomiting
. J Chin Anesthesiol
. 2007
;23
:454
–6
.© 2021 S. Karger AG, Basel
2021
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.
