Background: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymus on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time. Methods: The total phenolic content and gas chromatography-mass spectrometry metabolite profiling in leaves of C. scolymus have been evaluated. A clinical trial was subsequently carried out on 40 patients to determine the effect of C. scolymus on BP and BMI in hypertensive patients. The treatment group received capsules containing C. scolymus(500 mg twice daily) and the placebo group received starch powder for 8 weeks. Systolic blood pressure (SBP), diastolic blood pressure, and BMI were determined before and after the study. Results: A significant improvement of the BMI was seen in the C. scolymus group compared with the placebo group (p = 0.04). Conclusions: Our findings demonstrated that the consumption of C. scolymus powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients. Therefore, more trials are needed to confirm or reject the antihypertensive impact of artichoke.

1.
Wang
Y
,
Wang
QJ
.
The prevalence of prehypertension and hypertension among US adults according to the new joint national committee guidelines: new challenges of the old problem
.
Arch Intern Med
.
2004
Oct
;
164
(
19
):
2126
34
.
[PubMed]
0003-9926
2.
Lewington
S
,
Clarke
R
,
Qizilbash
N
,
Peto
R
,
Collins
R
;
Prospective Studies Collaboration
.
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
.
Lancet
.
2002
Dec
;
360
(
9349
):
1903
13
.
[PubMed]
0140-6736
3.
Ferrannini
E
,
Buzzigoli
G
,
Bonadonna
R
,
Giorico
MA
,
Oleggini
M
,
Graziadei
L
, et al
Insulin resistance in essential hypertension
.
N Engl J Med
.
1987
Aug
;
317
(
6
):
350
7
.
[PubMed]
0028-4793
4.
Jeppesen
J
,
Hein
HO
,
Suadicani
P
,
Gyntelberg
F
.
Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease
.
Arch Intern Med
.
2001
Feb
;
161
(
3
):
361
6
.
[PubMed]
0003-9926
5.
Appel
LJ
,
Brands
MW
,
Daniels
SR
,
Karanja
N
,
Elmer
PJ
,
Sacks
FM
;
American Heart Association
.
Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association
.
Hypertension
.
2006
Feb
;
47
(
2
):
296
308
.
[PubMed]
0194-911X
6.
Schiffrin
EL
.
Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment
.
Am J Hypertens
.
2004
Dec
;
17
(
12 Pt 1
):
1192
200
.
[PubMed]
0895-7061
7.
Lammers
AE
.
Predicting prognosis of children with pulmonary arterial hypertension: the importance of multimodal expert assessment
.
Heart
.
2014
Sep
;
100
(
17
):
1305
7
.
[PubMed]
1355-6037
8.
Husserl
FE
,
Messerli
FH
.
Adverse effects of antihypertensive drugs
.
Drugs
.
1981
Sep
;
22
(
3
):
188
210
.
[PubMed]
0012-6667
9.
Ardalani
H
,
Moghadam
MH
,
Rahimi
R
,
Soltani
J
,
Mozayanimonfared
A
,
Moradi
M
, et al
HassanpourMoghadam M, Rahimi R, Soltani J, Mozayanimonfared A, Moradi M, Azizi A: Sumac as a novel adjunctive treatment in hypertension: A randomized, double-blind, placebo-controlled clinical trial
.
RSC Advances
.
2016
;
6
(
14
):
11507
12
. 2046-2069
10.
Jandaghi
P
,
Noroozi
M
,
Ardalani
H
,
Alipour
M
.
Lemon balm: A promising herbal therapy for patients with borderline hyperlipidemia-A randomized double-blind placebo-controlled clinical trial
.
Complement Ther Med
.
2016
Jun
;
26
:
136
40
.
[PubMed]
0965-2299
11.
Yousefi
E
,
Zareiy
S
,
Zavoshy
R
,
Noroozi
M
,
Jahanihashemi
H
,
Ardalani
H
.
Fenugreek: A therapeutic complement for patients with borderline hyperlipidemia: A randomised, double-blind, placebo-controlled, clinical trial
.
Adv Integr Med
.
2017
;
4
(
1
):
31
5
. 2212-9588
12.
Sonnante
G
,
Pignone
D
,
Hammer
K
.
The domestication of artichoke and cardoon: from Roman times to the genomic age
.
Ann Bot
.
2007
Nov
;
100
(
5
):
1095
100
.
[PubMed]
0365-0812
13.
Lattanzio
V
,
Kroon
PA
,
Linsalata
V
,
Cardinali
A
.
Globe artichoke: a functional food and source of nutraceutical ingredients
.
J Funct Foods
.
2009
;
1
(
2
):
131
44
. 1756-4646
14.
Ben Salem
M
,
Affes
H
,
Ksouda
K
,
Dhouibi
R
,
Sahnoun
Z
,
Hammami
S
, et al
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits
.
Plant Foods Hum Nutr
.
2015
Dec
;
70
(
4
):
441
53
.
[PubMed]
0921-9668
15.
Speroni
E
,
Cervellati
R
,
Govoni
P
,
Guizzardi
S
,
Renzulli
C
,
Guerra
MC
.
Efficacy of different Cynara scolymus preparations on liver complaints
.
J Ethnopharmacol
.
2003
Jun
;
86
(
2-3
):
203
11
.
[PubMed]
0378-8741
16.
Misael
PC
,
Guadalupe
TM
,
Paola
DC
,
Carlos
RL
;
MISAEL PCE
.
DE GUADALUPE TMBM, DEL CASTILLO SGMP, CARLOS RLJ: Effect of Cynara scolymus (artichoke) in Homeopathic Doses on Body Mass Index in Obese and Overweight Patients
.
Biomed Pharmacol J
.
2014
;
7
(
2
):
525
33
. 0974-6242
17.
Roghani-Dehkordi
F
,
Kamkhah
AF
.
Artichoke leaf juice contains antihypertensive effect in patients with mild hypertension
.
J Diet Suppl
.
2009
;
6
(
4
):
328
41
.
[PubMed]
1939-0211
18.
Abdulmalik
O
,
Safo
MK
,
Chen
Q
,
Yang
J
,
Brugnara
C
,
Ohene-Frempong
K
, et al
5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells
.
Br J Haematol
.
2005
Feb
;
128
(
4
):
552
61
.
[PubMed]
0007-1048
19.
Khan
AU
,
Gilani
AH
.
Blood pressure lowering, cardiovascular inhibitory and bronchodilatory actions of Achillea millefolium
.
Phytother Res
.
2011
Apr
;
25
(
4
):
577
83
.
[PubMed]
0951-418X
20.
Singer
P
,
Jaeger
W
,
Berger
I
,
Barleben
H
,
Wirth
M
,
Richter-Heinrich
E
, et al
Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension
.
J Hum Hypertens
.
1990
Jun
;
4
(
3
):
227
33
.
[PubMed]
0950-9240
21.
Akhoundan
M
,
Shadman
Z
,
Jandaghi
P
,
Aboeerad
M
,
Larijani
B
,
Jamshidi
Z
, et al
The association of bread and rice with metabolic factors in type 2 diabetic patients
.
PLoS One
.
2016
Dec
;
11
(
12
):
e0167921
.
[PubMed]
1932-6203
22.
Li
H
,
Xia
N
,
Brausch
I
,
Yao
Y
,
Förstermann
U
.
Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells
.
J Pharmacol Exp Ther
.
2004
Sep
;
310
(
3
):
926
32
.
[PubMed]
0022-3565
23.
Guerrero
L
,
Castillo
J
,
Quiñones
M
,
Garcia-Vallvé
S
,
Arola
L
,
Pujadas
G
, et al
Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies
.
PLoS One
.
2012
;
7
(
11
):
e49493
.
[PubMed]
1932-6203
24.
Bundy
R
,
Walker
AF
,
Middleton
RW
,
Wallis
C
,
Simpson
HC
.
Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial
.
Phytomedicine
.
2008
Sep
;
15
(
9
):
668
75
.
[PubMed]
0944-7113
25.
Bartram
T
.
Bartram’s encyclopedia of herbal medicine
.
Hachette, UK
;
2013
.
26.
Rondanelli
M
,
Giacosa
A
,
Orsini
F
,
Opizzi
A
,
Villani
S
.
Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from Phaseolus vulgaris and Cynara scolymus
.
Phytother Res
.
2011
Sep
;
25
(
9
):
1275
82
.
[PubMed]
0951-418X
27.
Rondanelli
M
,
Opizzi
A
,
Faliva
M
,
Sala
P
,
Perna
S
,
Riva
A
, et al
Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial
.
Phytother Res
.
2014
Jan
;
28
(
1
):
33
41
.
[PubMed]
0951-418X
28.
Lee
EH
,
Kang
SM
.
Effects of diet food containing Jerusalem artichoke’s inulin, lotus leaf, and herb on weight and body fat of obesity university students
.
Journal of Applied Biological Chemistry
.
2009
;
52
(
1
):
8
14
.
29.
López-Molina
D
,
Navarro-Martínez
MD
,
Rojas Melgarejo
F
,
Hiner
AN
,
Chazarra
S
,
Rodríguez-López
JN
.
Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.)
.
Phytochemistry
.
2005
Jun
;
66
(
12
):
1476
84
.
[PubMed]
0031-9422
30.
Nowak
A
,
Klimowicz
A
,
Bielecka-Grzela
S
,
Piechota
M
.
[Inulin: a valuable nutritional component]
.
Ann Acad Med Stetin
.
2012
;
58
(
1
):
62
5
.
[PubMed]
1427-440X
31.
Kleessen
B
,
Schwarz
S
,
Boehm
A
,
Fuhrmann
H
,
Richter
A
,
Henle
T
, et al
Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers
.
Br J Nutr
.
2007
Sep
;
98
(
3
):
540
9
.
[PubMed]
0007-1145
32.
Morris
C
,
Morris
GA
.
The effect of inulin and fructo-oligosaccharide supplementation on the textural, rheological and sensory properties of bread and their role in weight management: a review
.
Food Chem
.
2012
Jul
;
133
(
2
):
237
48
.
[PubMed]
0308-8146
33.
Antal
M
,
Regöly-Mérei
A
,
Biró
L
,
Arató
G
,
Schmidt
J
,
Nagy
K
, et al
[Effects of oligofructose containing diet in obese persons]
.
Orv Hetil
.
2008
Oct
;
149
(
42
):
1989
95
.
[PubMed]
0030-6002
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