Background: Cancer-related fatigue (CRF) is one of the most common symptoms associated with cancer or its treatment. Objectives: The aim of the current study was to evaluate the effect of chickpea-based diet (Nokhodāb) on CRF in female breast cancer patients undertaking routine treatment. Method: Forty female patients with diagnosis of breast cancer were enrolled. The patients were asked to use a chickpea-based Persian diet daily for the period of 3 weeks. Symptom assessment was made for all women by the Cancer Fatigue Scale (CFS) and the Fatigue Severity Scale (FSS) questionnaires and Visual Analogue Scale (VAS). Results: CRF decreased significantly at the end of the study, compared to the beginning (p < 0.05). Mean of CFS was 40.72 before the intervention, while showing a significant decrease to 33.38 at the end of our study (p = 0.001). A comparison of FSS and VAS before and after intervention shows that FSS and fatigue VAS mean scores have a significant decline at the end (p < 0.001). Conclusions: Nokhodāb, as an available diet, could be a good choice for relieving CRF in breast cancer women. Traditional/complementary medicine may present some effective therapeutic suggestions for cancer complications.

1.
Bower
JE
.
Cancer-related fatigue—mechanisms, risk factors, and treatments
.
Nat Rev Clin Oncol
.
2014
Oct
;
11
(
10
):
597
609
.
[PubMed]
1759-4774
2.
Berger
AM
,
Abernethy
AP
,
Atkinson
A
,
Barsevick
AM
,
Breitbart
WS
,
Cella
D
, et al.
NCCN Clinical Practice Guidelines Cancer-related fatigue
.
J Natl Compr Canc Netw
.
2010
Aug
;
8
(
8
):
904
31
.
[PubMed]
1540-1405
3.
Curt
GA
,
Breitbart
W
,
Cella
D
,
Groopman
JE
,
Horning
SJ
,
Itri
LM
, et al.
Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition
.
Oncologist
.
2000
;
5
(
5
):
353
60
.
[PubMed]
1083-7159
4.
Lawrence
DP
,
Kupelnick
B
,
Miller
K
,
Devine
D
,
Lau
J
.
Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients
.
J Natl Cancer Inst Monogr
.
2004
;
2004
(
32
):
40
50
.
[PubMed]
1052-6773
5.
Safaee
A
,
Moghimi-Dehkordi
B
,
Tabatabaee
HR
,
Zeighami
B
.
Cancer related fatigue: a focus on breast cancer patients under chemotherapy
.
Open Breast Cancer J
.
2009
;
1
(
1
):
14
7
.
6.
Ryan
JL
,
Carroll
JK
,
Ryan
EP
,
Mustian
KM
,
Fiscella
K
,
Morrow
GR
.
Mechanisms of cancer-related fatigue
.
Oncologist
.
2007
;
12
Suppl 1
:
22
34
.
[PubMed]
1083-7159
7.
Parker
KP
,
Bliwise
DL
,
Ribeiro
M
,
Jain
SR
,
Vena
CI
,
Kohles-Baker
MK
, et al.
Sleep/Wake patterns of individuals with advanced cancer measured by ambulatory polysomnography
.
J Clin Oncol
.
2008
May
;
26
(
15
):
2464
72
.
[PubMed]
0732-183X
8.
Sood
A
,
Barton
DL
,
Bauer
BA
,
Loprinzi
CL
.
A critical review of complementary therapies for cancer-related fatigue
.
Integr Cancer Ther
.
2007
Mar
;
6
(
1
):
8
13
.
[PubMed]
1534-7354
9.
Mustian
KM
,
Sprod
LK
,
Janelsins
M
,
Peppone
LJ
,
Mohile
S
.
Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review
.
Oncol Hematol Rev
.
2012
;
8
(
2
):
81
8
.
[PubMed]
2052-3815
10.
Avicenna: Al-Qanun fi al-Tibb (The Canon of Medicine)
.
Tehran
:
Soroush Press
;
2005
.
11.
Mofid
B
,
Rezaeizadeh
H
,
Termos
A
,
Rakhsha
A
,
Mafi
AR
,
Taheripanah
T
, et al.
Effect of Processed Honey and Royal Jelly on Cancer-Related Fatigue: A Double-Blind Randomized Clinical Trial
.
Electron Physician
.
2016
Jun
;
8
(
6
):
2475
82
.
[PubMed]
2008-5842
12.
Razi
MZ
.
Al-Havi Fi Al-Tibb (Arabic)
.
Beirut
:
Dar Al Kotob Al-islmiyah
;
2000
.
13.
Jorjani
E
.
Zakhireye Kharazm Shahi (Treasure of Kharazm Shah)
[
In Persian
]
Tehran
:
Iranian Medical Academy
;
2001
.
14.
Aghili Shirazi
MH
. Moalejat-e Aghili (Persian). Tehran, Institute of Meical History, Islamic Medicine and Complementary Medicine; Iran Medical University,
2008
.
15.
Roy
F
,
Boye
J
,
Simpson
B
.
Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil
.
Food Res Int
.
2010
;
43
(
2
):
432
42
. 0963-9969
16.
Hamidpour
R
,
Hamidpour
M
,
Hamidpour
S
,
Shahlari
M
.
Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
.
J Tradit Complement Med
.
2015
Jan
;
5
(
2
):
66
70
.
[PubMed]
2225-4110
17.
Abdullaev
FI
.
Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.)
.
Exp Biol Med (Maywood)
.
2002
Jan
;
227
(
1
):
20
5
.
[PubMed]
1535-3702
18.
Han
H
,
Baik
BK
.
Antioxidant activity and phenolic content of lentils (Lens culinaris), chickpeas (Cicer arietinum L.), peas (Pisum sativum L.) and soybeans (Glycine max), and their quantitative changes during processing
.
Int J Food Sci Technol
.
2008
;
43
(
11
):
1971
8
. 0950-5423
19.
Frenkel
M
,
Abrams
DI
,
Ladas
EJ
,
Deng
G
,
Hardy
M
,
Capodice
JL
, et al.
Integrating dietary supplements into cancer care
.
Integr Cancer Ther
.
2013
Sep
;
12
(
5
):
369
84
.
[PubMed]
1534-7354
20.
Ghalayani
P
,
Emami
H
,
Pakravan
F
,
Nasr Isfahani
M
.
Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced oral mucositis: A randomized double-blinded clinical trial
.
Asia Pac J Clin Oncol
.
2017
Apr
;
13
(
2
):
e48
56
.
[PubMed]
1743-7555
21.
Jeong
JS
,
Ryu
BH
,
Kim
JS
,
Park
JW
,
Choi
WC
,
Yoon
SW
;
Jong Soo Jeong
;
Bong Ha Ryu
;
Jin Sung Kim
;
Jae Woo Park
;
Won Cheol Choi
;
Seong Woo Yoon
.
Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial
.
Integr Cancer Ther
.
2010
Dec
;
9
(
4
):
331
8
.
[PubMed]
1534-7354
22.
Barton
DL
,
Soori
GS
,
Bauer
BA
,
Sloan
JA
,
Johnson
PA
,
Figueras
C
, et al.
Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA
.
Support Care Cancer
.
2010
Feb
;
18
(
2
):
179
87
.
[PubMed]
0941-4355
23.
Johnson
RL
,
Block
I
,
Gold
MA
,
Markwell
S
,
Zupancic
M
.
Effect of methylphenidate on fatigue in women with recurrent gynecologic cancer
.
Psychooncology
.
2010
Sep
;
19
(
9
):
955
8
.
[PubMed]
1057-9249
24.
Jean-Pierre
P
,
Morrow
GR
,
Roscoe
JA
,
Heckler
C
,
Mohile
S
,
Janelsins
M
, et al.
A phase 3 randomized, placebo-controlled, double-blind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy: a University of Rochester Cancer Center Community Clinical Oncology Program Research base study
.
Cancer
.
2010
Jul
;
116
(
14
):
3513
20
.
[PubMed]
0008-543X
25.
de Souza Fêde
AB
,
Bensi
CG
,
Trufelli
DC
,
de Oliveira Campos
MP
,
Pecoroni
PG
,
Ranzatti
RP
, et al.
Multivitamins do not improve radiation therapy-related fatigue: results of a double-blind randomized crossover trial
.
Am J Clin Oncol
.
2007
Aug
;
30
(
4
):
432
6
.
[PubMed]
0277-3732
26.
Mücke
M
,
Cuhls
H
,
Peuckmann-Post
V
,
Minton
O
,
Stone
P
,
Radbruch
L
;
Mochamat
.
Pharmacological treatments for fatigue associated with palliative care
.
Cochrane Database Syst Rev
.
2015
May
;(
5
):
CD006788
.
[PubMed]
1469-493X
27.
Liu
L
,
Mills
PJ
,
Rissling
M
,
Fiorentino
L
,
Natarajan
L
,
Dimsdale
JE
, et al.
Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy
.
Brain Behav Immun
.
2012
Jul
;
26
(
5
):
706
13
.
[PubMed]
0889-1591
28.
Wang
XS
,
Williams
LA
,
Krishnan
S
,
Liao
Z
,
Liu
P
,
Mao
L
, et al.
Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy
.
Brain Behav Immun
.
2012
Jul
;
26
(
5
):
699
705
.
[PubMed]
0889-1591
29.
Bar-El Dadon
S
,
Abbo
S
,
Reifen
R
.
Leveraging traditional crops for better nutrition and health - The case of chickpea
.
Trends Food Sci Technol
.
2017
;
64
:
39
47
. 0924-2244
30.
Pittaway
JK
,
Robertson
IK
,
Ball
MJ
.
Chickpeas may influence fatty acid and fiber intake in an ad libitum diet, leading to small improvements in serum lipid profile and glycemic control
.
J Am Diet Assoc
.
2008
Jun
;
108
(
6
):
1009
13
.
[PubMed]
0002-8223
31.
Reeves
M
,
Winkler
E
,
Mccarthy
N
,
Lawler
S
,
Terranova
C
,
Hayes
S
, et al.
The Living Well after Breast Cancer™ Pilot Trial: a weight loss intervention for women following treatment for breast cancer
.
Asia Pac J Clin Oncol
.
2017
Jun
;
13
(
3
):
125
36
.
[PubMed]
1743-7555
32.
Mittal
G
,
Vadhera
S
,
Brar
AP
,
Soni
G
.
Protective role of chickpea seed coat fibre on N-nitrosodiethylamine-induced toxicity in hypercholesterolemic rats
.
Exp Toxicol Pathol
.
2009
Jul
;
61
(
4
):
363
70
.
[PubMed]
0940-2993
33.
Zia-ul-Haq
M
,
Khan
BA
,
Landa
P
,
Kutil
Z
,
Ahmed
S
,
Qayum
M
, et al.
Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea
.
Acta Pol Pharm
.
2012
Jul-Aug
;
69
(
4
):
707
11
.
[PubMed]
0001-6837
34.
Roy
F
,
Boye
JI
,
Simpson
BK
.
Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil
.
Food Res Int
.
2010
;
43
(
2
):
432
42
. 0963-9969
35.
Bhandari
PR
.
Crocus sativus L. (saffron) for cancer chemoprevention: A mini review
.
J Tradit Complement Med
.
2015
Jan
;
5
(
2
):
81
7
.
[PubMed]
2225-4110
36.
Mizuma
H
,
Tanaka
M
,
Nozaki
S
,
Mizuno
K
,
Tahara
T
,
Ataka
S
, et al.
Daily oral administration of crocetin attenuates physical fatigue in human subjects
.
Nutr Res
.
2009
Mar
;
29
(
3
):
145
50
.
[PubMed]
0271-5317
37.
Pasalar
M
,
Choopani
R
,
Mosaddegh
M
,
Kamalinejad
M
,
Mohagheghzadeh
A
,
Fattahi
MR
, et al.
Efficacy of jollab in the treatment of depression in dyspeptic patients: a randomized double-blind controlled trial
.
J Evid Based Complementary Altern Med
.
2015
Apr
;
20
(
2
):
104
8
.
[PubMed]
2156-5872
38.
Khan
R
,
Sharma
M
,
Kumar
L
,
Husain
SA
,
Sharma
A
.
Cinnamon extract exhibits potent anti-proliferative activity by modulating angiogenesis and cyclooxygenase in myeloma cells
.
J Herb Med
.
2016
;
6
(
3
):
149
56
. 2210-8033
39.
Sedighi
M
,
Nazari
A
,
Faghihi
M
,
Rafieian-Kopaei
M
,
Karimi
A
,
Moghimian
M
, et al.
Protective effects of cinnamon bark extract against ischemia-reperfusion injury and arrhythmias in rat
.
Phytother Res
.
2018
Oct
;
32
(
10
):
1983
91
.
[PubMed]
0951-418X
40.
Kwon
HK
,
Jeon
WK
,
Hwang
JS
,
Lee
CG
,
So
JS
,
Park
JA
, et al.
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells
.
Cancer Lett
.
2009
Jun
;
278
(
2
):
174
82
.
[PubMed]
0304-3835
41.
Suleria
HA
,
Butt
MS
,
Anjum
FM
,
Saeed
F
,
Khalid
N
.
Onion: nature protection against physiological threats
.
Crit Rev Food Sci Nutr
.
2015
;
55
(
1
):
50
66
.
[PubMed]
1040-8398
42.
Mahoney
SE
,
Davis
JM
,
Murphy
EA
,
McClellan
JL
,
Pena
MM
.
Dietary quercetin reduces chemotherapy-induced fatigue in mice
.
Integr Cancer Ther
.
2014
Sep
;
13
(
5
):
417
24
.
[PubMed]
1534-7354
43.
Pintha
K
,
Yodkeeree
S
,
Pitchakarn
P
,
Limtrakul
P
.
Anti-invasive activity against cancer cells of phytochemicals in red jasmine rice (Oryza sativa L.)
.
Asian Pac J Cancer Prev
.
2014
;
15
(
11
):
4601
7
.
[PubMed]
1513-7368
44.
De Smet
S
,
Vossen
E
.
Meat: the balance between nutrition and health. A review
.
Meat Sci
.
2016
Oct
;
120
:
145
56
.
[PubMed]
0309-1740
45.
Pasalar
M
,
Choopani
R
,
Mosaddegh
M
,
Kamalinejad
M
,
Mohagheghzadeh
A
,
Fattahi
MR
, et al.
Efficacy and safety of jollab to treat functional dyspepsia: a randomized placebo-controlled clinical trial
.
Explore (NY)
.
2015
May-Jun
;
11
(
3
):
199
207
.
[PubMed]
1550-8307
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.