Objective: This analysis aims to identify, on the basis of the results of randomized controlled trials (RCTs), whether acupuncture therapy can alleviate menopausal symptoms and promote health-related quality of life. Methods: We included RCTs that directly compared any type of acupuncture with sham acupuncture in treating menopause-related symptoms and which were published from January 1, 2010 to December 31, 2016 in 6 electronic databases. Two authors performed this work independently; ‘risk-of-bias' assessment and data extraction were also independently performed by these 2 review authors. The outcomes are presented as scores of the menopause rating scale (MRS), which represents the self-assessment of patients. Results: Six studies were included. Our analysis found that acupuncture can reduce the MRS score in menopausal women by the end of the treating period (2-3 months, on average) and even in the follow-up period (1-3 months), not only in the total score but also in each subscale score. But the grade of evidence is very low. Conclusions: Both the total score and the subgroup analysis strongly indicated that acupuncture can alleviate menopause-related symptoms. However, the evidence is not very strong. Thus, further studies about the efficiency of acupuncture on menopausal symptoms based on well-designed trials are needed.

1.
Dibonaventura MD, Wagner JS, Alvir J, Whiteley J: Depression, quality of life, work productivity, resource use, and costs among women experiencing menopause and hot flashes: a cross-sectional study. Prim Care Companion CNS Disord 2012;14(6).
2.
Stuenkel CA, Santen RJ: An introduction to the endocrine society clinical practice guideline on treatment of symptoms of the menopause. Post Reprod Health 2016;22:6-8.
3.
Main C, Knight B, Moxham T, Gabriel SR, Sanchez GL, Roque IFM, Bonfill CX: Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev 2013;(4):CD002229.
4.
Bakken K, Fournier A, Lund E, Waaseth M, Dumeaux V, Clavel-Chapelon F, Fabre A, Hemon B, Rinaldi S, Chajes V, Slimani N, Allen NE, Reeves GK, Bingham S, Khaw KT, Olsen A, Tjonneland A, Rodriguez L, Sanchez MJ, Etxezarreta PA, Ardanaz E, Tormo MJ, Peeters PH, van Gils CH, Steffen A, Schulz M, Chang-Claude J, Kaaks R, Tumino R, Gallo V, Norat T, Riboli E, Panico S, Masala G, Gonzalez CA, Berrino F: Menopausal hormone therapy and breast cancer risk: impact of different treatments. The European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2011;128:144-156.
5.
Ee C, Xue C, Chondros P, Myers SP, French SD, Teede H, Pirotta M: Acupuncture for menopausal hot flashes: a randomized trial. Ann Intern Med 2016;164:146-154.
6.
Bastian LA, Smith CM, Nanda K: Is this woman perimenopausal? JAMA 2003;289:895-902.
7.
Heinemann K, Ruebig A, Potthoff P, Schneider HP, Strelow F, Heinemann LA, Do MT: The menopause rating scale (MRS) scale: a methodological review. Health Qual Life Outcomes 2004;2:45.
8.
Nedeljkovic M, Tian L, Ji P, Deglon-Fischer A, Stute P, Ocon E, Birkhauser M, Ausfeld-Hafter B: Effects of acupuncture and Chinese herbal medicine (Zhi Mu 14) on hot flushes and quality of life in postmenopausal women: results of a four-arm randomized controlled pilot trial. Menopause 2014;21:15-24.
9.
Kim DI, Jeong JC, Kim KH, Rho JJ, Choi MS, Yoon SH, Choi SM, Kang KW, Ahn HY, Lee MS: Acupuncture for hot flushes in perimenopausal and postmenopausal women: a randomised, sham-controlled trial. Acupunct Med 2011;29:249-256.
10.
Sunay D, Ozdiken M, Arslan H, Seven A, Aral Y: The effect of acupuncture on postmenopausal symptoms and reproductive hormones: a sham controlled clinical trial. Acupunct Med 2011;29:27-31.
11.
Kim KH, Kang KW, Kim DI, Kim HJ, Yoon HM, Lee JM, Jeong JC, Lee MS, Jung HJ, Choi SM: Effects of acupuncture on hot flashes in perimenopausal and postmenopausal women - a multicenter randomized clinical trial. Menopause 2010;17:269-280.
12.
Wen X: Clinical research of acupuncture on menopause-related symptoms of menopause transition. Chin J Inter Med 2015;5:1752-1756.
13.
Bao C: Clinical observation on perimenopausal syndrome treated by yin-yang adjusted acupuncture. J Clin Acupunct Mox 2015;4:7-10.
14.
Schlaeger JM, Gabzdyl EM, Bussell JL, Takakura N, Yajima H, Takayama M, Wilkie DJ: Acupuncture and acupressure in labor. J Midwifery Womens Health 2017;62:12-28.
15.
Zhang J, Shang H, Gao X, Ernst E: Acupuncture-related adverse events: a systematic review of the Chinese literature. Bull World Health Organ 2010;88:915-921.
16.
Hayhoe S: Insomnia: can acupuncture help? Pain Manag 2017;7:49-57.
17.
Lau CH, Wu X, Chung VC, Liu X, Hui EP, Cramer H, Lauche R, Wong SY, Lau AY, Sit RS, Ziea ET, Ng BF, Wu JC: Acupuncture and related therapies for symptom management in palliative cancer care: systematic review and meta-analysis. Medicine (Baltimore) 2016;95:e2901.
18.
Dong B, Chen Z, Yin X, Li D, Ma J, Yin P, Cao Y, Lao L, Xu S: The efficacy of acupuncture for treating depression-related insomnia compared with a control group: a systematic review and meta-analysis. Biomed Res Int 2017;2017:9614810.
19.
Lee SH, Lim SM: Acupuncture for insomnia after stroke: a systematic review and meta-analysis. BMC Complement Altern Med 2016;16:228.
20.
Lin YF, Liu ZD, Ma W, Shen WD: Hazards of insomnia and the effects of acupuncture treatment on insomnia. J Integr Med 2016;14:174-186.
21.
Lee SH, Lim S: Clinical effectiveness of acupuncture on Parkinson disease: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2017;96:e5836.
22.
Kim KN, Chung SY, Cho SH: Efficacy of acupuncture treatment for functional dyspepsia: a systematic review and meta-analysis. Complement Ther Med 2015;23:759-766.
23.
Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, Hou LH, Hu ZX, Shao XG, Ge J, Zhang JF, Xue HY, Xu XF, Liang RN, Ma HX, Yang HW, Li WL, Huang DM, Sun Y, Hao CF, Du SM, Yang ZW, Wang X, Yan Y, Chen XH, Fu P, Ding CF, Gao YQ, Zhou ZM, Wang CC, Wu TX, Liu JP, Ng E, Legro RS, Zhang H: Effect of acupuncture and clomiphene in Chinese women with polycystic ovary syndrome: a randomized clinical trial. JAMA 2017;317:2502-2514.
24.
Dodin S, Blanchet C, Marc I, Ernst E, Wu T, Vaillancourt C, Paquette J, Maunsell E: Acupuncture for menopausal hot flushes. Cochrane Database Syst Rev 2013;(7):CD007410.
25.
Cho SH, Whang WW: Acupuncture for vasomotor menopausal symptoms: a systematic review. Menopause 2009;16:1065-1073.
26.
Borrelli F, Ernst E: Alternative and complementary therapies for the menopause. Maturitas 2010;66:333-343.
27.
Chiu HY, Pan CH, Shyu YK, Han BC, Tsai PS: Effects of acupuncture on menopause-related symptoms and quality of life in women in natural menopause: a meta-analysis of randomized controlled trials. Menopause 2015;22:234-244.
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