...A.H. Bittles Consanguineous marriage has long been a controversial topic, with particular attention focused on adverse health outcomes. Unfortunately, the studies that have been conducted on consanguinity to date have usually lacked control for important sociodemographic variables, such as maternal...

... and paternal relatives’ offspring. Large and consanguineous families contributed to the description of a number of new autosomal recessive conditions and to identify new loci and genes. Genetic disorders are common in Tunisia, where most people are receptive to health guidelines. Selective abortion...

... is before 120 days (17 weeks) of gestation [ 7 ]. Genetic screening Abortion Consanguinity β-Thalassemia The advancements in molecular genetics and the completion of the human genome project have raised the possibility of genetic diagnosis [ 1 ]. Markers for both monogenic as well as complex...

...Mostafa Saadat Background: Using folktales we can find some aspects of social customs. Here, I show the situation of consanguineous marriages in folktales from different Iranian populations and try to compare it with the present situation of consanguineous marriages. Methods: The study includes...

...Mohamed A. Seliem; Issam H. Bou-Holaigah; Nouriya Al-Sannaa Background: Familial aggregation of congenital heart disease (CHD) has been well described in different populations, in particular those with a high consanguinity rate. Extensive genetic study of affected families has improved...

... from 7.4 in 1976 to 3.7 in 2004. Consanguineous marriages are traditionally favored, with the preferred marriage partner being the offspring of the father’s brother. First-cousin marriages declined from 28.5% for marriages contracted between 1950 and 1979 to 19.5% for marriages contracted after 1980...

...L.I. Al-Gazali; R. Alwash; Y.M. Abdulrazzaq The UAE society is cosmopolitan, but the indigenous inhabitants are traditional with puritanical values despite their exposure to other vastly different cultures and habits. Marriages between consanguineous couples are still the norm rather than...

...L.I. Al-Gazali Aims: To assess the level of understanding of genetic advice given in the Genetic Clinic and attitudes toward consanguineous marriages, and prenatal, abortion and preconception diagnoses. Methods: One hundred couples underwent structured interviews, and various social and educational...

... including β-thalassemia, sickle cell gene (βS) and abnormal hemoglobins is significantly increased and poses a major public health problem in the UAE. The number of homozygous patients strongly suggests a high degree of consanguinity among the UAE nationals. With 50 different β-thalassemia alleles, UAE...

.... These events have resulted in the admixture of the original Arabs with other populations extending from east and south Asia to Europe and Africa. Their demographic features include high rates of consanguinity, a large family size and a rapid population growth. There is a high frequency of autosomal recessive...

...A.H. Bittles Considerable attention is paid to the role of consanguineous marriage as a causative factor in the prevalence of genetic disorders. At the same time, the potential influence of community endogamy on overall levels of homozygosity and disease profiles remains largely under-investigated...

... proportion of neonatal deaths were clustered in a small group of women. The univariate analysis showed a statistically significant association between a number of maternal-level parameters (e.g., mother’s age at birth, level of formal education, employment status, religious affiliation, and consanguinity...

...P.C. Corry Objective: The northern English city of Bradford has a population of 370,000. In recent years the Pakistani community has gradually expanded in number, and in 2001 contributed 41.4% of births in the city. There is a very high level of consanguineous marriage in this community...

...G. Kumaramanickavel; B. Joseph; A. Vidhya; T. Arokiasamy; N. Shridhara Shetty Objective: Consanguineous marriage is a widely practised social custom in Asia and northern Africa. In south India, Dravidian Hindus have contracted consanguineous marriages for over 2,000 years. In the present study...

... of 30 cases of metachromatic leukodystrophy, 13 cases of Tay-Sachs disease and its variants, 11 cases of Sandhoff disease, and 1 case each of Niemann-Pick disease and multiple sulphatase deficiency. The clinical features were similar to earlier reports. Parental consanguinity was present in 63.6...

...Susan Becker; Zohair Al Halees Background: Consanguinity may be a risk factor that contributes to congenital heart disease in an inbred population, particularly among first cousins; with high rates of intermarriage between relatives, consanguinity is associated with congenital heart disease...