This special issue of Community Genetics reviews some of the most important developments in medical genetics in key countries of Latin America. Contributions to this issue were prepared for a special consultation of the World Health Organization held in Porto Alegre, Brazil, on June 19, 2003. Latin America is a region of medium- to low-income countries characterized by socioeconomic problems, with large segments of the population living in poverty and extreme disparities in the distribution of wealth. A rise in chronic diseases typical of the processes of industrialization and urbanization coexists with the persistence of nutritional and infectious diseases characteristic of poverty and underdevelopment. Over the last 2 decades of the 20th century, birth defects and genetic disorders have increased their share of morbidity and mortality, and tertiary-care-based genetic services have developed in urban areas. Although privatization of health care is eroding the public sector, the public institutions continue to be the main providers of genetic services for the bulk of the population and the leaders in research. The development of clinical genetics in the region is concentrated in tertiary-care centers in large cities, although a recent trend began extending genetic services to the community.

Keywords:
Abortion, Counseling, Genetic services, Latin America, Public health genetics
1.
Boulyjenkov V: The role of the World Health Organization in promoting medical genetics in Latin America. Community Genet 2004;7:70–73.
2.
Kofman-Alfaro S, Penchaszadeh VB: Community genetic services in Latin America and regional network of medical genetics. Recommendations of a World Health Organization consultation. Community Genet 2004;7:157–159.
3.
World Bank: World Development Indicators. Washington, World Bank, 2003.
4.
Pan American Health Organization: Health Conditions in the Americas. Washington, Pan American Health Organization, 2002.
5.
World Health Organization: Maternal mortality in 2000: Estimates developed by WHO, UNICEF and UNFPA. Geneva, World Health Organization, 2003. www.who.int/reproductive-health/publications/maternal_mortality_2000
6.
Alan Guttmacher Institute: Sharing Responsibility. Women, Society and Abortion Worldwide. New York, Alan Guttmacher Institute, 1999.
7.
World Atlas of Birth Defects. International Center for Birth Defects of the International Clearinghouse for Birth Defects Monitoring Systems, 2nd ed. Geneva, World Health Organization, 2003.
8.
World Health Organization: Services for the Prevention and Management of Genetic Disorders and Birth Defects in Developing Countries. Geneva, World Health Organization, 1999.
9.
Penchaszadeh VB, Christianson AL, Giugliani R, Boulyjenkov V, Katz M: Services for the prevention and management of genetic disorders and birth defects in developing countries. Community Genet 1999;2:196–201.
10.
Penchaszadeh VB, Beiguelman B: Medical genetic services in Latin America. Report of a meeting of experts. Rev Panam Salud Publica 1998;3:409–420.
11.
Penchaszadeh VB: Community genetic services in Latin America. Challenges and perspectives. Community Genet 2000;3:124–127.
12.
Giugliani R, Matte U: The Latin-American Network of Human Genetics. Community Genet 2004;7:74–75.
13.
Castilla EE, Orioli IM: ECLAMC: The Latin-American Collaborative Study of Congenital Malformations. Community Genet 2004;7:76–94.
14.
Brazilian National Genome Project Consortium: The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa Consortium of the Organization for Nucleotide Sequencing and Analysis. Nature 2000;406:151–157.
15.
Camargo AA, Samaia HP, Dias-Neto E, et al: The contribution of 700,000 ORF sequence tags to the definition of the human transcriptome. Proc Natl Acad Sci USA 2001;8:12103–12108.
16.
Orioli IM, Vieira AR, Castilla EE, Ming JE, Muenke M: Mutational analysis of the Sonic hedgehog gene in 220 newborns with oral clefts in a South American (ECLAMC) population. Am J Med Genet 2002;108:12–15.
© 2004 S. Karger AG, Basel
2004
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