Abstract
Latin America is a region of medium-to-low income countries with health indicators in transition towards patterns seen in developed countries, with growing importance of birth defects and genetic disorders as causes of morbidity and mortality. Over the past 20 years, tertiary-care-based genetic services have been developing in urban areas, although their population impact is still very low. Cuba is an exception, as genetic services were conceived from the beginning as primary-care-based and with specific community health objectives. Clinical geneticists in the region have recently began a trend towards extending genetic services to the community, with lukewarm support from state public health officials.
References
1.
Pan American Health Organization 1998: Health Conditions in the Americas. Washington, Pan American Health Organization, 1998.
2.
World Bank: World Development Report 1993. New York, Oxford University Press, 1993.
3.
Penchaszadeh VB, Beiguelman B (eds): Medical Genetic Services in Latin America. WHO publication WHO/HGN/CONS/MGS/98.4. Human Genetics Programme. Geneva, WHO, 1998.
4.
Barreiro CZ, Negrotti T, Penchaszadeh VB: Prevalence of genetic disease in a pediatric referral hospital. Excerpta Med Int Congr Ser 1976;397:60.
5.
Penchaszadeh VB: Frequency and characteristics of birth defects admissions to a pediatric hospital in Venezuela. Am J Med Genet 1979;3:359–369.
6.
Carnevale A, Hernandez M, Reyes R, Paz F, Sosa C: The frequency and economic burden of genetic disease in a pediatric hospital in Mexico City. Am J Med Genet 1985;20:665–675.
7.
UNICEF: The State of the World’s Children. Oxford, Oxford University Press, 1998.
8.
United Nations Population Fund: The State of World Population. New York, United Nations Population Fund, 1998.
9.
The Allan Guttmacher Institute: Clandestine Abortion: A Latin American Reality. New York, The Alan Guttmacher Institute, 1994.
10.
World Atlas of Birth Defects: International Center for Birth Defects and World Health Organization, Rome and Geneva.
11.
Penchaszadeh VB, Christianson AL, Giugliani R, Boulyjenkov V, Katz M: Services for the prevention and management of genetic disorders and birth defects in developing countries. Community Genet 1999;2:196–201.
12.
Pan American Health Organization: Prevention and Control of Genetic Diseases and Congenital Defects. Report of an Advisory Group. Scientific Publication 460. Washington, PAHO, 1984.
13.
Penchaszadeh VB, Beiguelman B: Medical genetic services in Latin America. Report of a meeting of experts. Pan Am J Public Health 1998;3:409–420.
14.
Pan American Health Organization: PAHO/WHO Consultation on the development of PAHO strategy on congenital disorders. Washington, Oct 1998. PAHO internal publication, Washington, 1998.
15.
Heredero L: Comprehensive national genetic program in a developing country – Cuba; in Kuliev A, Greendale K, Penchaszadeh VB, Paul NW (eds): Genetic Services Provision: An International Perspective. Birth Defects Orig Article Ser 1992;28(3):52–57.
16.
Granda H, Gispert S, Dorticos A, Martin M, et al: Cuban programme for prevention of sickle cell disease. Lancet 1991;337:152–154.
17.
Granda H, Gispert S, Martinez G, Gomez M, et al: Results from a reference laboratory for prenatal diganosis of sickle cell disorders in Cuba. Prenat Diagn 1994;14:659–662.
18.
Dorticos-Balea A, Martin-Ruiz M, Hechevarria-Fernandez P, Robaina-Castellanos MS, et al: Reproductive behavior of couples at risk for sickle cell disease in Cuba: A follow-up study. Prenat Diagn 1997;17:737–742.
19.
Rodriguez L, Sanchez R, Hernandez J, Carrillo L, et al: Results of 12 years’ combined maternal serum alpha-fetoprotein screening and ultrasound fetal monitoring for prenatal detection of fetal malformations in Havana City, Cuba. Prenat Diagn 1997;4:301–304.
20.
Penchaszadeh VB, Heredero L, Punales-Morejon D, Rojas I, Perez ET: Genetic counseling training in Cuba. Am J Hum Genet 1997;61(4)suppl A1099.
© 2001 S. Karger AG, Basel
2001
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.