Objective: To increase accrual among Hispanics to the Cancer Genetics Network national cancer genetics registry. Methods: Drawing from South Texas cancer registries, 444 Hispanic men and women were randomly assigned to one of three experimental conditions: standard direct-mailed procedures (X1), X1 plus culturally tailored materials (X2), and X2 plus interpersonal phone contact (X3). Participants were also surveyed about the effectiveness of the education materials and the phone contact. A refusal survey was provided for those who declined to join the study. Results: A total of 154 individuals joined the Cancer Genetics Network. The X3 condition yielded the greatest accrual (43.2%) compared to X1 (30.9%) and X2 (29.9%; p < 0.05). Tailored materials appeared to have no effect but were highly regarded. The main reasons for not participating were a lack of interest and time requirements. Conclusion: Interpersonal communication can have a powerful effect on recruitment. However, more research is needed to determine the cost-efficacy of more labor-intensive approaches to registry accrual.

U.S. Census Bureau: United States Census 2000. U.S. Department of Commerce, Economics and Statistics Administration.
National Cancer Institute: Facts & Figures. http://www.cancer.gov/clinicaltrials/facts-and-figures/page2#B9, retrieved December 4, 2006.
Advani AS, Atkeson B, Brown CL, Peterson BL, Fish L, Johnson JL, Gockerman JP, Gautier M: Barriers to participation of African-American patients with cancer in clinical trials: a pilot study. Cancer 2003;97:1499–1506.
Fouad MN, Partridge E, Wynn T, Green BL, Kohler C, Nagy S: Statewide Tuskegee Alliance for clinical trials. A community coalition to enhance minority participation in medical research. Cancer 2001;91:237–241.
Kaluzny A, Brawley O, Garson-Angert D, Shaw J, Godley P, Warnecke R, Ford L: Assuring access to state-of-the-art care for U.S. minority populations: the first 2 years of the Minority-Based Community Clinical Oncology Program. J Natl Cancer Inst 1993;85:1945–1950.
Outlaw FH, Bourjolly JN, Barg FK: A study on recruitment of black Americans into clinical trials through a cultural competence lens. Cancer Nurs 2000;23:444–451.
Paskett ED, Cooper MR, Stark N, Ricketts TC, Tropman S, Hatzell T, Aldrich T, Atkins J: Clinical trial enrollment of rural patients with cancer. Cancer Pract 2002;10:28–35.
Pinto HA, McCaskill-Stevens W, Wolfe P, Marcus AC: Physician perspectives on increasing minorities in cancer clinical trials; an Eastern Cooperative Oncology Group (ECOG) Initiative. Ann Epidemiol 2000;10:S78–S84.
Randall-David B, Stark N, Gierisch J, Torti F: ‘What do they know about it?’ How the North Carolina public views cancer clinical trials: implications for primary care doctors. N C Med J 2001;62:281–285.
Robertson NL: Clinical trial participation. Viewpoints from racial/ethnic groups. Cancer 1994;74:2687–2691.
Robinson SB, Ashley M, Haynes MA: Attitude of African-Americans regarding prostate cancer clinical trials. J Community Health 1996;21:77–87.
Fouad MN, Partridge E, Green BL, Kohler C, Wynn T, Nagy S, Churchill S: Minority recruitment in clinical trials: a conference at Tuskegee, researchers and the community. Ann Epidemiol 2000;10:S35–S40.
Green BL, Partridge EE, Fouad MN, Kohler C, Crayton EF, Alexander L: African American attitudes regarding cancer clinical trials and research studies: results from focus group methodology. Ethn Dis 2000;10:76–86.
Grunfeld E, Zitzelsberger L, Coristine M, Aspelund F: Barriers and facilitators to enrollment in cancer clinical trials: qualitative study of the perspectives of clinical research associates. Cancer 2002;95:1577–1583.
McCaskill-Stevens W, Pinto H, Marcus AC, Comis R, Morgan R, Plomer K, Schoentgen S: Recruiting minority cancer patients into cancer clinical trials: a pilot project involving the Eastern Cooperative Oncology Group and the National Medical Association. J Clin Oncol 1999;17:1029–1039.
Woods MN, Harris KJ, Mayo MS, Catley D, Scheibmeir M, Ahluwalia JS: Participation of African Americans in a smoking cessation trial: A quantitative and qualitative study. J Natl Med Assoc 2002;94:609–618.
Kornblith AB, Kemeny M, Peterson BL, Wheeler J, Crawford J, Bartlett N, Fleming G, Graziano S, Muss H, Cohen HJ; Cancer and Leukemia Group B: Survey of oncologists’ perceptions of barriers to accrual of older patients with breast carcinoma to clinical trials. Cancer 2002;95:989–996.
Sateren WB, Trimble EL, Abrams J, Brawley O, Breen N, Ford L, Mc Cabe M, Kaplan R, Smith M, Ungerleider R, Christian MC: How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials. J Clin Oncol 2002;20:2109–2117.
Simon MS, Du W, Flaherty L, Philip PA, Lorusso P, Miree C, Smith D, Brown DR: Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center. J Clin Oncol 2004;22:2046–2052.
Brown DR, Topcu M: Willingness to participate in clinical treatment research among older African Americans and Whites. Gerontologist 2003;43:62–72.
Comis RL, Miller JD, Aldige CR, Krebs L, Stoval E: Public attitudes toward participation in cancer clinical trials. J Clin Oncol 2003;21:830–835.
Collaborative Ocular Melanoma Study Group: Sociodemographic and clinical predictors of participation in two randomized trials: findings from the Collaborative Ocular Melanoma Study COMS report No. 7. Control Clin Trials 2001;22:526–537.
Kemeny MM, Peterson BL, Kornblith AB, Muss HB, Wheeler J, Levine E, Bartlett N, Fleming G, Cohen HJ: Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol 2003;21:2268–2275.
Krailo MD, Bernstein L, Sullivan-Halley J, Hammond GD: Patterns of enrollment on cooperative group studies. An analysis of trends from the Los Angeles County Cancer Surveillance Program. Cancer 1993;71:3325–3330.
Ford JG, Howerton MW, Bolen S, Gary TL, Lai GY, Tilburt J, Gibbons MC, Baffi C, Wilson RF, Feuerstein CJ, Tanpitukpongse P, Powe NR, Bass EB: Knowledge and access to information on recruitment of underrepresented populations to cancer clinical trials. Evidence Report: Technology assessment No. 122 (Prepared by the John Hopkins University Evidence-based Practice Center under contract No. 290-02-0018.) AHRQ Publication No. 05-E019-2. Rockville, Agency for Healthcare Research and Quality, 2005.
Millon-Underwood S, Sanders E, Davis M: Determinants of participation in state-of-the-art cancer prevention, early detection/screening, and treatment trials among African Americans. Cancer Nurs 1993;16:25–33.
Friebel TM, Beutler RA, Lee SM, Bernhardt BA, Helzlsouer KJ, Griffin CA: Active recruitment increases enrollment in a hereditary cancer registry. J Clin Epidemiol 2004;57:1172–1176.
Sutherland HJ, Lacroix J, Knight J, Andrulis IL, Boyd NF: The cooperative familial registry for breast cancer studies: design and first year recruitment rates in Ontario. J Clin Epidemiol 2001;54:93–98.
Hughes C, Peterson SK, Ramirez A, Gallion KJ, McDonald PG, Skinner CS, Bowen D: Minority recruitment in hereditary breast cancer research. Cancer Epidemiol Biomarkers Prev 2004;13:1146–1155.
Vogt TM, Glass A, Glasgow RE, La Chance PA, Lichtenstein E: The safety net: a cost-effective approach to improving breast and cervical cancer screening. J Womens Health 2003;12:789–798.
Anton-Culver H, Ziogas A, Bowen D, Finkelstein D, Griffin C, Hanson J, Isaacs C, Kasten-Sportes C, Mineau G, Nadkarni P, Rimer B, Schildkraut J, Strong L, Weber B, Winn D, Hiatt R, Nayfield S: The Cancer Genetics Network: recruitment results and pilot studies. Community Genet 2003;6:171–177.
Bowen DJ, Allen JD, Vu T, Johnson RE, Fryer-Edwards K, Hart A Jr: Theoretical foundations for interventions designed to promote informed decision making for cancer screening. Ann Behav Med 2006;32:202–210.
Bandura A: Social Foundations of Thought and Action. Englewood Cliffs, Prentice-Hall, 1986.
Ramirez AG, Talavera GA, Villarreal R, Suarez L, Mc Alister A, Trapido E, Perez-Stable E, Marti J: Breast cancer screening in regional Hispanic populations. Health Educ Res 2000;15:559–568.
Cabral DN, Napoles-Springer AM, Miike R, McMillan A, Sison JD, Wrensch MR: Population- and community-based recruitment of African Americans and Latinos: The San Francisco Bay Area Lung Cancer Study. Am J Epidemiol 2003;158:272–279.
SPSS for Windows, release 13.0. Chicago, SPSS Inc, 2005.
Altman DG, Schulz KF, Moher D, Egger M, Davidoff F, Elbourne D, Gotzsche PC, Lang T: The revised CONSORT statement for reporting randomized trials: explanation and elaboration. Ann Intern Med 2001;134:663–694.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.