Objectives: The aim of this study was to examine the knowledge of and attitudes on the use of genetic information for medical purposes among the general public of Japan and to identify how the knowledge and attitudes correlate with gender, age and related factors. Methods: A cross-sectional survey using a self-administered questionnaire was conducted from June to July 2004. Stratified random samples of 500 adults aged from 20 to 69 years, living in A-ward, Tokyo, Japan, were analyzed using a χ2 test, t test and discriminant analysis (stepwise method). Results: Findings showed ‘interested in the use of genetic information for medical research’, ‘useful for making effective use of medicine’ and ‘useful for determining disorders to which one may be susceptible in the future’ as the three related factors that influenced discrimination in respondents’ attitudes. Of these, ‘interested in the use of genetic information for medical research’ had a standardized discriminant coefficient of 0.946, indicating greatest relevance to discriminating respondents’ attitudes. The factors ‘useful for making effective use of medicine’ and ‘useful for determining disorders to which one may be susceptible in the future’ exhibited the next highest discriminant relevance. There was no significant difference in gender and age. Conclusions: This study clarified the knowledge of and attitudes on the use of genetic information for medical purposes among the general public of Japan.

Bruno JS: Who cares about the double helix? Nature 2003;422:803–804.
International Human Genome Sequencing Consortium: Initial sequencing and analysis of the human genome. Nature 2001;409:860–921.
The International HapMap Consortium: The International HapMap Project. Nature 2003;426:789–796.
International Human Genome Sequencing Consortium: Finishing the euchromatic sequence of the human genome. Nature 2004;431:931–945.
Van Ommen GJ: The Human Genome Project and the future of diagnostics, treatment and prevention. J Inherit Metab Dis 2002;3:183–188.
Moore CA, Khoury MJ, Bradley LA: From genetics to genomics: using gene-based medicine to prevent disease and promote health in children. Semin Perinatol 2005;3:135–143.
Masui T: Infrastructure of the use of personal information is indispensable for current genome research (in Japanese). Med Tribune2003;2:74.
Masui T, Takada Y: Ethical, legal, and social issues of research – New phase of genome research desperately requires social understanding and safeguards on the use of medical records and other personal information (in Japanese with English abstract). Yakugaku Zasshi 2003;123:107–119.
Masui T: A meaning of UK Biobank project (in Japanese). Jurist2003;1247:29–36.
Davis DS: Discovery of children’s carrier status for recessive genetic disease: some ethical issues. Genet Test 1998;2:323–327.
Wertz DC, Fanos JH, Reilly PR: Genetic testing for children and adolescents. Who decided? JAMA 1994;272:875–881.
Lynch EL, Doherty RJ, Gaff CL, Macrae FA, Lindeman GJ: ‘Cancer in the family’ and genetic testing: implications for life insurance. Med J Aust 2003;179:480–483.
Joly Y, Knopper BM, Godard B: Genetic information and insurance: a ‘real’ risk? Eur J Hum Genet 2003;11:561–564.
Collins FS, McKusick VA: Implications of the Human Genome Project for medical science. JAMA 2001;285:540–544.
Olick RS: Disclosing genetic information to family members: do old paradigms fit the new medicine? N J Med 2000;97:43–46.
Everett M: Can you keep a (genetic) secret? The genetic privacy movement. J Genet Couns 2004;13:273–291.
Mould A: Implications of genetic testing: discrimination in life insurance and future directions. J Law Med 2003;10:470–487.
Knudsen LE: Global gene mining and the pharmaceutical industry. Toxicol Appl Pharmacol 2005;207(suppl):679–683.
Rabino I: Genetic testing and its implications: human genetics researchers grapple with ethical issues. Sci Technol Human Values 2003;28:365–402.
Wertz DC, Fletcher JC, Nippert I, Wolff G, Ayme S: In focus: has patient autonomy gone too far? Geneticists’ views in 36 nations. Am J Bioeth 2002;2:W21.
Nomura S, Kawai S, Fukushima T, Katoh H, Osawa G: The attitude of Japanese physicians regarding genetic service for autosomal dominant polycystic kidney disease (ADPKC). Jpn J Hum Genet 1994;39:427–431.
Lapham EV, Kozma C, Weiss JO: Genetic discrimination: perspectives of consumers. Science 1996;274:621–624.
Low L, Kings S, Wilkie T: Genetic discrimination in life insurance: empirical evidence from a cross sectional survey of genetic support groups in the United Kingdom. BMJ 1998;317:1632–1635.
Armstrong K, Weber B, FitzGerald G, Hershey JC, Pauly MV, Lemaire J, Subramanian K, Asch DA: Life insurance and breast cancer risk assessment: adverse selection, genetic testing decisions, and discrimination. Am J Med Genet A 2003;120:359–364.
Kass NE, Hull SC, Natowicz MR, Faden RR, Planting L, Gostin LO, Slutsman J: Medical privacy and the disclosure of personal medical information: the beliefs and experiences of those with genetic and other clinical conditions. Am J Med Genet A 2004;128:261–270.
Johnson S, Kass NE, Natowicz M: Disclosure of personal medical information: differences among parents and affected adults for genetic and non-genetic conditions. Genet Test 2005;9:269–280.
Hoeyer K, Olofsson BO, Mjorndal T, Lynoe N: Informed consent and biobanks: a population-based study of attitudes towards tissue donation for genetic research. Scand J Public Health 2004;32:224–229.
Kettis-Lindblad A, Ring L, Viberth E, Hansson MG: Genetic research and donation of tissue samples to biobanks. What do potential sample donors in the Swedish general public think? Eur J Public Health 2006;16:433–440.
The University of Tokyo College of Arts and Science: Statistics of the Humanities and Social Sciences (in Japanese). Tokyo, University of Tokyo Publication Association, 1994, pp 9–10.
Huston P, Rowan M: Qualitative studies. Their role in medical research. Can Fam Physician 1998;44:2453–2458.
Henneman L, Timmermans DR, Van der Wal G: Public experiences, knowledge and expectations about medical genetics and the use of genetic information. Community Genet 2004;7:33–43.
Catz DC, Green NS, Tobin JN, Lloyd-Puryear MA, Kyler P, Umemoto A, Cernoch J, Brown R, Wolman F: Attitudes about genetics in underserved, culturally diverse populations. Community Genet 2005;8:161–172.
Ikeda W, Fujita H: Public awareness of genetic testing for hereditary cancer susceptibility and its related factors (in Japanese with English abstract). Jpn J Health Hum Ecol 2003;69:1–12.
Roberts LW, Geppert CM, Warner TD, Green Hammond KA, Rogers M, Smrcka J, Roberts BB: Perspectives on use and protection of genetic information in work settings: results of a preliminary study. Soc Sci Med 2005;60:1855–1858.
Muto K: Attitudes toward pre-symptomatic testing and social services for families with Huntington’s disease in Japan (in Japanese with English abstract). Med Soc 1998;8:67–82.
Chattopadhyay A: Understanding of genetic information in higher secondary students in northeast India and the implications for genetics education. Cell Biol Educ 2005;4:97–104.
Takebe H: Genome education for doctors and medical staffs (in Japanese). Iden 2003;57:64–68.
Kawashima H: Difference of ethical issues between Japan and USA in genetic medical treatment; in Fujiki N, Meisar D (eds): Human Genome Research and Society (in Japanese). Ibaraki, Eubios Ethics Institute, 1992, pp 152–154.
Rose A, Peters N, Shea JA, Armstrong K: The association between knowledge and attitudes about genetic testing for cancer risk in the United States. J Health Commun 2005;10:309–321.
Knoppers BM, Hirtle M, Lormeau S: Ethical issues in international collaborative research on the human genome: the HGP and HGDP. Genomics 1996;34:272–282.
Lone DL: Whose genes are they? The Human Genome Diversity Project. J Health Soc Policy 1999;10:51–66.
China: Presidential Decree No. 33 of 27 October 1994 promulgating the Law of the People’s Republic of China on the protection of maternal and child health. Int Dig Health Legis 1995;46:39–42.
Scotson J: Eugenics in China. Lancet 1995;346:509.
Takebe H: Bioethics in human gene analysis (in Japanese). J Jpn Assoc Bioethics 2000;11:11–15.
Munn M, Skinner PO, Conn L, Horsma HG, Gregory P: The involvement of genome researchers in high school science education. Genome Res 1999;9:597–607.
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