American Indians have arrived at a critical point in their more than 500-year history with the United States Government. With the advent of the new bio-revolution, a number of tribes have voiced vehement opposition to genetic patenting, creation of cell lines, transgenic experimentation and cloning. While many are opposed to the Human Genome Diversity Project, Human Genome Project and diversity research currently being conducted by the Indian Health Service, a few embrace the beneficial aspects of biomedical/biogenetic research. Moreover, an increasing number of Indians see the need for and are seeking genetic counseling and other services. This paper briefly describes some of the issues associated with developing and implementing effective genetic services within Native American communities. Problems of access, perception of services, previous experience with genetics and cultural and other barriers are discussed. Recommendations also are rendered to assist health professionals in the development of services.

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