...S. Ripa; L. Ferrante; M. Prenna The pharmacokinetic profile of azithromycin, after oral ingestion of 500 mg, was determined in 10 healthy volunteers. Statistical and biochemical reason seemed to indicate a zero-order absorption of the drug. The disposition of azithromycin was described by a two...

... was carried out by applying a single-compartment kinetic model with zero-order absorption. The apparent duration of absorption (T) was about 1 h for all subjects. The peak plasma concentrations (C max ) were 17.89 ± 1.82 μ g/ml, and the mean plasma half-life during β -phase was 1.17 ± 0.14 h. The area under...