... Venezolano de Investigaciones Científicas, Departamento de Biología Celular, Escuela de Biología, and Departamento de Parasitología, Instituto de Zoología Tropical, Facultad de Ciencias, Universidad Central de Venezuela, Centro Médico Docente La Trinidad, Caracas, Venezuela Key Words Trypanosoma cruzi Chagas...

... higher doses were required. Its toxicity on cell proliferation in tissue culture was moderate. In vitro assays on amastigote forms of Trypanosoma cruzi were carried out using cultures of Vero cells infected with metacyclic trypomastigotes. For one compound (1) trypanocidal activity resembled...

... were screened for activity against Trypanosoma cruzi in vitro. The results are discussed here with reference to the structure of the compounds tested. Attempts to elucidate the mode of action of active acridines are also included. The most active compounds that were tested were 9-thioacridanones and 9...