...Berna Ozbek; Gulten Otuk Background: Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa . Methods: The in vitro activities of tobramycin and levofloxacin in combination...

... to dicloxacillin the staphylococci were characterized by an increase in the number of crosswalls, rifampin produced thickening of the cell wall, but only minimal changes were induced by gentamicin. Intracellular electrondense aggregates were observed in P. aeruginosa after exposure to imipenem, tobramycin...

... for the pulmonary deterioration in these patients. Tobramycin has variable inhibitory effects on these organisms, but in many isolates this inhibition is increased in vitro by exposure to the diuretic, amiloride. Aerosolized amiloride has been shown to be of clinical benefit in CF. The basis for this synergy...

...Robert C. Cohn; Lois Rudzienski Antibiotic-resistant Burkholderia cepacia is an important pathogen in cystic fibrosis. We have previously shown enhanced tobramycin susceptibility of most strains in the presence of the drug amiloride. Others have shown similar findings in the presence of cationic...

...Kenneth J. Tack; L.D. Sabath Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under...

...A. Kropec; F. Daschner The in vitro activity of the 4-quinolone compound fleroxacin (Ro-23–6240) was compared with that of enoxacin, ofloxacin, cefepime (BMY-28142), ceftazidime, ceftriaxone, and tobramycin against a total of 30 recent clinical isolates of Acinetobacter calcoaceticus subsp...

...Ashir Kumar; Rosslyn Wofford-McQueen; Ralph C. Gordon For 16 isolates of Pseudomonas cepacia from patients with cystic fibrosis, synergism was determined by the killing curve method, utilizing various combinations of antibiotics [ticarcillin (Ti), rifampin (Ri), tobramycin (To), imipenem (Im...

...Milap C. Nahata The objective of this study was to assess the impact of intravenous infusion systems on the pharmacokinetic parameters of tobramycin in newborn infants. Thirty infants (gestational age 28–38 weeks; birth weight 0.8–3.5 kg; postnatal age 4–10 days) with presumed or proven gram...

...Walter H Traub; Dierk Bauer; Marlene Spohr Five antimicrobial drugs (ceftazidime, ciprofloxacin, imipenem, piperacillin and tobramycin) and two human, intravenously applicable, IgG immunoglobulin preparations (Psomaglobin®, Polyglobin N®) were examined alone and in various combinations...

...Dario Birolini; Marcos F. Moraes; Olavo Soares de Souza The activity of aztreonam (a β-lactam antibiotic with specific activity against gram-negative bacteria) was evaluated and compared with that of tobramycin in hospitalized patients with severe intra-abdominal infections due to gram-negative...

...Milap C. Nahata; Dwight A. Powell; Diane Durrell; John P. Glazer The delivery of tobramycin was studied at the flow rates of 2, 4 and 6 ml/h after injection into the various sites of IVAC, IMED and Auto Syringe infusion systems. The actual times were markedly longer than the predicted times...

...B. Olier; G. Viotte; J.P. Morin; J.P. Fillastre Many factors play a role in aminoglycoside nephrotoxicity. To study the influence of dosage regimens, Wistar rats were injected for 8 days with a total daily dose of 10, 20, or 50 mg/kg tobramycin intraperitoneally either in one single (1...

...J.R. DiPersio; T.L. Krafczyk The in vitro activity of netilmicin was compared to gentamicin, tobramycin and amikacin against 461 strains of glucose fermenting and nonfermenting bacteria. The minimum inhibitory concentrations of netilmicin, gentamicin and tobramycin against the majority...

...P. Sandven; J. Lassen; O. Solberg; Ø. Evandt The minimal inhibitory concentration for tobramycin and gentamicin against 488 clinical isolates of Enterobacteriaceae, Staphylococcus aureus and Pseudomonas spp. were obtained on three different solid media. The results obtained on Antibiotic...

...Kjetil Melby; Tore Midtvedt; Olle Dahl 6,042 strains of Staphylococcus aureus , Streptococcusfaecalis , Proteus mira-bilis , Escherichia coli , Kiebsiella sp . and Pseudomonas sp . were tested against tobramycin and gentamicin. Among all species studies, except Pseudomonas sp , gentamicin turned...

...William L. Dibb; Vibecke Asphaug Kjellevold; Asbjørn Digranes The in vitro activities of azlocillin, carbenicillin, ceftriaxone, piperacillin, N-formimidoyl thienamycin (N-f thienamycin) and tobramycin have been compared against clinical isolates of Pseudomonas aeruginosa (n = 100...

...O. Brückner; M. Alexander; H. Collmann Concentrations of tobramycin in cerebrospinal fluid (CSF) and serum of neurosurgical and of meningitis patients were determined following systemic application of 80-mg doses. Tobramycin was detectable only in 8 tests out of 17 in CSF of 11 neurosurgical...

...J. Tselentis; N.J. Legakis; K.J. Nicolas; K. Melissinos; J. Papavassiliou Netilmicin was compared with sisomicin, tobramycin and amikacin against 65 recent clinical enterobacterial isolates found to be highly resistant to gentamicin (MIC ≥ 80 μg/ml). Netilmicin showed a high activity against 20 out...

...Michael H. Cynamon; Paul A. Granato The in vitro activities of moxalactam, GR 20263, and N-formimidoyl thienamycin were compared to those of cephalothin, cefazolin, cefamandole, cefoxitin, and tobramycin against 152 strains of Enterobacteriaceae and staphylococci . The results showed...

...J. Stessman; J. Michel; T. Sacks The recovery rate of gentamicin and tobramycin from uraemic sera was between 50 and 70% using a bioassay method which gave a 90% recovery rate from normal sera. This difference was not seen with streptomycin or kanamycin. The recovery rate from uraemic sera could...