...Z.D. Jiang; H.L. DuPont In vitro inhibitory activity of rifaximin is directed against Gram-positive and Gram-negative, aerobic and anaerobic bacteria. It is effective in the treatment of gastrointestinal infections when given orally because of the high concentration of the drug remaining in the gut...

...Iva Pelosini; Carmelo Scarpignato Rifaximin is a poorly absorbed semisynthetic rifamycin derivative with a broad spectrum of antibacterial activity including Gram-positive and Gram-negative bacteria, both aerobes and anaerobes. Although originally developed for the treatment of infectious diarrhea...

... Pseudomembranous colitis Clostridium difficile Rifaximin Clostridium difficile -associated diarrhea Chemotherapy 2005;51(suppl 1):81 89 DOI: 10.1159/000081993 Antibiotic-Associated Diarrhea and Pseudomembranous Colitis: Are They Less Common with Poorly Absorbed Antimicrobials? Christina M. Surawicz...

...Charles D. Ericsson; Herbert L. DuPont Rifaximin matches the criteria for an ideal agent for the treatment of infectious diarrhea. It has excellent activity against a broad range of enteropathogens. It is nonabsorbable, which may help explain its excellent side effect profile and lack of emergence...

... (ammonia) and precipitating factors (NBZDs) suggests that the use of nonabsorbable antibiotics such as rifaximin may be useful in preventing episodes of HE in patients with liver cirrhosis. 11 4 2005 Chemotherapy 2005;51(suppl 1):90 95 DOI: 10.1159/000081994 Management of Hepatic Encephalopathy...

... therapeutic approaches used is reviewed. 11 4 2005 Chemotherapy 2005;51(suppl 1):103 109 DOI: 10.1159/000081996 Treatment of Small Intestine Bacterial Overgrowth and Related Symptoms by Rifaximin Michele Di Stefano Gino Roberto Corazza Gastroenterology Unit, IRCCS S. Matteo Hospital, University...

... disease. Rifaximin, a rifamycin-derived antibiotic, is characterized by a wide range of antibacterial activity and a very low systemic absorption. Some preliminary data show its efficacy in severe active ulcerative colitis, pouchitis and prevention of postoperative recurrence in Crohn’s disease. 11 4...

... are commonly used in the treatment of inflammatory complications of diverticular disease. Data from open labelled and randomized controlled trials do suggest the efficacy of rifaximin in obtaining symptomatic relief in patients with diverticular disease. Approximately 30% therapeutic gain compared to fiber...

...Carmelo Scarpignato; Iva Pelosini Rifaximin (4-deoxy-4′-methylpyrido[1′,2′-1,2]imidazo- [5,4-c]-rifamycin SV) is a synthetic antibiotic designed to modify the parent compound, rifamycin, in order to achieve low gastrointestinal (GI) absorption while retaining good antibacterial activity. Both...

...Anna Marchese; Angelo Salerno; Adelaide Pesce; Eugenio A. Debbia; Gian Carlo Schito Background: Rifaximin is a rifamycin derivative characterized by a wide antibacterial activity. This drug is neither absorbed by the gastrointestinal tract nor inactivated by gastric juices, and exerts its action...