..., respectively: 180.9, 198.7, 482.0, 580.0 and 690.1 for chloroquine; 3.4,3.4,9.2,4.0 and 5.8 for mefloquine; 21.9,10.5,40.7, 40. land 48.7 for quinine; 136.7,58.8,116.4,29.4 and 95.4 for cycloguanil, and 48.3, 57.5, 47.4, 61.5 and 37.8 for pyrimethamine. Before cryopreservation they were 172.5, 141.5, 453.2...

...Hooi Hoon Ang; Chan Kit Lam; Mak Joon Wah Six clones were derived from each Plasmodium falciparum isolate obtained from Malaysia, Africa and Thailand and were characterized against type II antifolate drugs, cycloguanil and pyrimethamine using the modified in vitro microtechnique. Results showed...

...D.E. Schwartz; E. Weidekamm; I. Mimica; P. Heizmann; R. Portmann Fansimef® is a new antimalarial combination containing pyrimethamine, sulfadoxine and mefloquine in the weight proportions 1+20+10. It has been designed to fight plasmodia resistant to the presently used antimalarial drugs...

...Michael D. Edstein The pharmacokinetics of sulfadoxine (SULF) and pyrimethamine (PYR) were studied in 7 healthy volunteers after a single oral dose of Fansidar®. A comparison was made between the pharmacokinetics of the components of Fansidar calculated from whole blood and plasma data. The mean...

...E. Weidekamm; D.E. Schwartz; U.C. Dubach; B. Weber Fansimef® is a new oral schizonticide which contains pyrimethamine (P), sulfadoxine (S) and mefloquine (M) in a weight ratio of 1:20:10. This antimalarial combination is highly active against multi-resistant Plasmodium falciparum and in vitro...

...N.S. Wang; X.B. Guo; Q.D. Liu; L.C. Fu; G.Q. Li; K. Arnold The oral single-dose pharmacokinetics and bioavailability of mefloquine (M) in combination with pyrimethamine (P) and sulfadoxine (S) from a single non-lacquered tablet (NL; M 250 mg, P 25 mg, S 500 mg) and two lacquered tablets (L; M 125...

...W. Peters Sulfalene has a marked inhibitory action against a drug-sensitive strain of P. berghei in mice. The ED 90 ranges between 0.25 and 1.0 mg/kg (given intraperitoneally daily for 4 days). The action is potentiated when the sulphonamide is given in a 1:1 mixture with pyrimethamine...

... ST); 20 patients received a combination of sulfametopyrazine and pyrimethamine (group SP). On the day of diagnosis and for 5 successive days after the beginning of treatment, peripheral blood, fever and various other findings characteristic of malaria were checked. In 22/22 patients of group ST...

..., cycloguanil and pyrimethamine, before and after subculturing them in vitro for a period of 3 years, was studied. Methods: Thirty fresh clones were obtained from five different blood samples infected with P. falciparum isolates. They were tested for their susceptibility to the above drugs during...