... exposure to O-demethylated or hydroxylated midostaurin metabolites. We also show that hematologists react to risk perception by replacing posaco-nazole with antifungals like micafungin or isavuconazole, which lack a strong inhibition of CYP3A4 and fail to modify midostaurin pharmacokinetics...

... in the healthcare settings and in the community, trimethoprim/sulfamethoxazole (TMP/SMX) has been suggested as a convenient treatment option. However, the appropriate dosage regimen of TMP/SMX is unclear. Objective: This study aimed to examine the pharmacokinetics/pharmacodynamics (PK/PD) of TMP/SMX against S...

...Dagan Osborne Lonsdale; Jeffrey Lipman; Amelia Livermore; Brett McWhinney; Jacobus P.J. Ungerer; Jason A. Roberts Dosing of amoxicillin-clavulanic acid in critical illness is difficult as β-lactam pharmacokinetics are altered by physiological changes and therapies initiated in the intensive care...

... blood samples were collected at 0, 1, 4, and 8 h post antibiotic administration. Samples were analyzed for total and unbound cefazolin concentrations. Protein binding was ∼60%. Clearance was reduced due to impaired renal function. The pharmacokinetics of cefazolin appear to not be affected by ECMO...

...) and posaconazole (PCZ) remain the most widely used antifungals for the prophylaxis and treatment of IFD. However, VCZ and PCZ are liable for drug-drug interactions and show a pharmacokinetic variability that requires therapeutic drug monitoring (TDM). Isavuconazole (IVZ) is a newest generation triazole antifungal...

... Pegfilgrastim Granulocyte colony-stimulating factor Pharmacokinetics Granulocyte colony-stimulating factor (G-CSF), a hematopoietic colony-stimulating factor (CSF), stimulates the proliferation, differentiation and functional activity of neutrophil precursors [ 5 ]. An understanding of the role...

... the pharmacokinetics (PK) of ertapenem in colorectal tissue via population PK modeling. Patients and Methods: Patients ≧18 years requiring surgical intervention at the colon and/or rectum were eligible ( ClinicalTrials.gov identifier: NCT 00535652). Tissue and blood samples were taken during surgery after a single...

...B. Frey Tirri; J. Bitzer; B. Geudelin; J. Drewe Background/Aims: Intravaginal pentamycin is a polyene macrolide with a broad spectrum of antimicrobial activity and is effective in various forms of infectious vaginitis. We evaluated the safety, tolerability and pharmacokinetics of escalating doses...

...A. Goudah; S. Hasabelnaby Background: Moxifloxacin is a new fourth-generation 8-methoxy fluoroquinolone developed primarily for the treatment of community-acquired pneumonia and upper respiratory tract infections. The aim of the study was to investigate the plasma pharmacokinetics characteristic...

...S. Ripa; L. Ferrante; M. Prenna The pharmacokinetic profile of azithromycin, after oral ingestion of 500 mg, was determined in 10 healthy volunteers. Statistical and biochemical reason seemed to indicate a zero-order absorption of the drug. The disposition of azithromycin was described by a two...

.... The serum half-life was found to be approximately 4 h. Flurithromycin ethylsuccinate Pharmacokinetics Serum levels Pharm acology Chemotherapy 1994;40:157-160 RC..EM. aCtoticnuaz3zaa AALMRL.aoLnmzeoaplfoiabrmehe3 CUIDMnlnesiilnvitaviietnceul,arotslIepittRmaoyleyfeosnMefta,MerPdciiihlceaarnarl,neMdal...

...Zhu Zhu; Ai-Xia Wang; Yan Li The pharmacokinetics of ceftriaxone were studied in 5 healthy Chinese volunteers who received single doses of 1 or 2 g by intravenous infusion at 2-weekly intervals. Only 50 μ1 of plasma was required for the determination of plasma ceftriaxone concentrations using...

... to (against preadult and encysted larvae) or significantly lower than (against migrating larvae) that of ABZ with the same formulation. The pharmacokinetic profiles of ABZSO as measured by HPLC showed no significant differences in the Cmax and AUC following administration of ABZ formulated as a suspension...

...Chin-chung Lin; Elaine Radwanski; Chryzanta Korduba; Melton Affrime; Mitchell N. Cayen The pharmacokinetics of isepamicin, a broad-spectrum aminoglycoside antibiotic, was studied in man after intramuscular administration. Two groups each of 6 volunteers received isepamicin for 10 consecutive days...

... utilizing time-concentration-kill curves. A pharmacodynamic model was used to simulate one-compartment pharmacokinetics for single-, double-, or triple-drug combinations utilizing two different elimination half-lives (T 1/2 ). Each duplicate experiment was conducted for 24 h in cation-supplemented Mueller...

...Abdel-Moneim M. Osman; Samir F. Saad; Sherif Y. Saad; Abdel-Bast A. El-Aaser; Mahmoud M.E. El-Merzabani The pharmacokinetics of two commonly used anticancer drugs, methotrexate (MTX) and 5-fluorouracil (5-FU), were investigated in normal and bilharzial-infested mice. Liver glu-cose-6-phosphatase...

... to in the content or advertisements. Cefotaxime Pharmacokinetics Tissue cage fluid Bovine Pharmacology Chemotherapy 1994;40:221-226 RHMRGdRBQReuuuuBlsbiercuiaohsogcicaahzhizaozbzob Comisión de Investigaciones CCBiuáetenentdoírfsiacAadsierdeFsea,rlLmaaPaPcroolavlotiang;cíaia, de...

..., instructions or products referred to in the content or advertisements. Malaria Halofantrine Pharmacokinetics Plasmodium falciparum Bruno Cenni Bruno Betschart Department of Medical Parasitology, Swiss Tropical Institute, Basel, Switzerland Pharmacology Chemotherapy 1995;41:153-158 The in vitro...

...Akira Saito The pharmacokinetics of S-1108, an ester-type oral cephalosporin antibiotic, were studied in healthy male volunteers in a crossover study. This study focused especially on the effects on S-1108 absorption of (1) a meal, (2) concomitant administration of ceruletide diethylamine (a drug...

...Tom Bergan; Helge Michalsen; Anna Stina Malmborg; Svend Stenvang Pedersen; Tanja Pressler; Olav Trond Storrøsten; Birgitta Standvik The pharmacokinetics of imipenem (MK-787) and cilastatin (MK-791) were studied in 30 patients with cystic fibrosis (CF) receiving the drug for therapeutic purposes...