... biomarkers have been verified to predict the efficacy of chemotherapy for locally advanced gastric cancer. Methods: An MTT assay was used to determine the cell viability after cisplatin or oxaliplatin treatment. Western blotting and immunohistochemistry were utilized to examine the secreted frizzled-related...

..., instructions or products referred to in the content or advertisements. Advanced gastric cancer 5-Fluorouracil Cisplatin Oxaliplatin Platinum Meta-analysis Gastric or gastroesophageal junction cancer is the fifth most common tumor, and it is the third most deadly cancer in males, with 783,000...

...Hideki Nagase; Fumio Nakagawa; Junji Uchida Background/Aim: A phase 3 trial of S-1, leucovorin (LV), and oxaliplatin for treating gastric cancer is now underway. However, the antitumor efficacy of the combination has not yet been examined in an in vivo preclinical study. This study examined...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FOLFOX Oxaliplatin Duration Chemotherapy Complication Survival Although the survival rate of patients...

...Mark Waddle; Myra Irvin; Eva Gupta; Martin Gibbs; Tanya S. Kakar; Nicole A. Gannon; Jennifer R. Arthurs; Deborah L. Fischer; Sikander Ailawadhi Oxaliplatin is one of the most commonly used drugs for patients with colorectal cancer. It has rarely been associated with disseminated intravascular...

...-related issues. Methods: We collected data from 27 MBC patients treated with gemcitabine and oxaliplatin (GEMOX) at our institution between June 2009 and April 2015. The patients were heavily pretreated, and all had previously been exposed to anthracyclines and taxanes. Results: We achieved a complete...

...François Ghiringhelli; Veronique Lorgis; Julie Vincent; Sylvain Ladoire; Boris Guiu Background: The aim of this study was to evaluate the efficacy and tolerability of hepatic arterial infusion (HAI) of gemcitabine plus oxaliplatin as second-line treatment for unresectable locally advanced...

...Ithar Gataa; George Emile; Marie-Anne Loriot; François Goldwasser; Jérôme Alexandre Background: Although the efficiency of oxaliplatin in patients with advanced ovarian cancer has been demonstrated, it is not commonly used. In cells, oxaliplatin is metabolized by the enzymes belonging...

...Xiao Jun Xiang; Ling Zhang; Feng Qiu; Feng Yu; Zheng Yu Zhan; Miao Feng; Jun Yan; Jian Guo Zhao; Jian Ping Xiong Objective: This study aimed at assessing the efficacy and safety of oxaliplatin plus oral capecitabine (XELOX regimen) as first-line chemotherapy in elderly patients with advanced...

...Antoine Hollebecque; Olivier Bouché; Olivier Romano; Elodie Scaglia; Stéphane Cattan; Philippe Zerbib; Alexandra Heurgue; Stéphanie Lagarde; Christophe Mariette; Jean-Pierre Triboulet; François-René Pruvot; Mohamed Hebbar Backgrounds: The combination gemcitabine-oxaliplatin (GEMOX) is frequently...

...Xiao Jun Xiang; Feng Qiu; Jian Ping Xiong; Ling Zhang; Feng Yu; Miao Feng; Zheng Yu Zhan Objective: This study aimed at evaluating the efficacy and safety of epirubicin, oxaliplatin, and capecitabine (EOX) in advanced gastric cancer (AGC) patients in the Chinese population. Patients and Methods...

... to determine the efficacy and tolerability of capecitabine and oxaliplatin (XELOX) given every 3 weeks in combination in patients with AGC. Methods: Patients with previously untreated AGC received intravenous oxaliplatin 130 mg/m 2 over 2 h on day 1 plus oral capecitabine 1,000 mg/m 2 twice daily on days 1–14...

... study to evaluate the efficacy and safety of docetaxel and oxaliplatin in metastatic urothelial cancer patients who had received prior platinum therapy. Patients and Methods: Patients with metastatic urothelial cancer, who had disease progression after platinum therapy, were treated with docetaxel 75 mg...

...Jae Yun Lim; Jae Yong Cho; Kyung Jin Oh; Seung Ho Choi; Sang In Lee; Hei-Cheul Jeung Background: The aim of this clinical study was to evaluate the efficacy of combination chemotherapy of oxaliplatin, leucovorin and continuous-infusion 5-fluorouracil (5-FU) for advanced gastric cancer. Methods...

...Sung Yong Oh; Gyeong-Won Lee; Hoon Gu Kim; Tae Hyo Kim; Hyun Jin Kim; Jung Hun Kang Background: Biliary tract cancers are among the most aggressive tumors with a poor prognosis. We conducted a phase II study on combination chemotherapy consisting of S-1 and oxaliplatin in previously untreated...

... of FOLFOX regimens (5-fluorouracil and L -leucovorin combined with oxaliplatin) are widely used for the treatment of advanced colorectal cancer, the neurotoxicity caused by oxaliplatin is often problematic. The aim of this observational study was to assess the safety and efficacy of a modified version...

...Hui-Yan Luo; Rui-Hua Xu; Li Zhang; Yu-Hong Li; Yan-Xia Shi; Tong-Yu Lin; Bing Han; Feng Wang; Miao-Zhen Qiu; You-Jian He; Zhong-Zhen Guan Background: To evaluate the efficacy and toxicity of an oxaliplatin, fluorouracil (5-FU), and folinic acid (FOLFOX-6) combination therapy in patients...

... and caspase 3 activation were examined. Results: In terms of cytotoxicity, the derivatives ranked in the order of oxaliplatin > cisplatin > nedaplatin > carboplatin, being comparable with that for the level of platinum accumulated in LLC-PK 1 cells. Lactate dehydrogenase release and DNA fragmentation...

...A. Moschidis; A. Papageorgiou; K. Atmatzidis; K. Tsalis; E. Moschidis; J. Livanis; E. Chrysogelou; D. Mourelatos; D. Tsavdaridis; N. Harlaftis Oxaliplatin (OX) and gemcitabine (GEM) are both drugs with proven clinical activity in various tumor types, have no overlapping toxic side effects...

...Ivan Popov; Svetislav Jelic; Zoran Krivokapic; Marjan Micev; Dragana Babic; Zdravko Zdrale One hundred and ninety-three patients were assigned to receive 5-FU/LV, irinotecan and oxaliplatin in five different sequential treatment groups: Mayo Clinic Regimen (MCR) + LV5FU2 (group A); MCR + irinotecan...