... of aminoglycosides does not increase the risk of ototoxicity specifically associated with each compound. 9 9 2009 © 1990 S. Karger AG, Basel 1990 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

...Silvio Dionisotti; Francesco Bamonte; Peter Leung; William G. Kramer; Ennio Ongini To complement a study on aminoglycoside dosing regimen and ototoxicity in the guinea pig, we designed an experiment to examine: (1) the effect of dosing regimen on guinea pig pharmacokinetic parameters, and (2...

...Peter Echeverria; Doris Fina; Susan Norton; Arnold L. Smith In a effort to estimate the incidence of clinical ototoxicity in children we reviewed the charts of 374 patients who had serum gentamicin concentration determined 30 min before (‘trough value’) and at the pharmacologic peak after...

...Hai Ying Yin; Xiu Fang Ma; Fang Liu; Ming Xia; An Ting Xu Background: Geranylgeranylacetone (GGA) has the ability to induce heat shock proteins and to protect cells from apoptotic insults. This study aims to investigate whether GGA has a protective effect on cisplatin (CDDP) ototoxicity. Methods...

...Ken-ichi Watanabe; Ken Jinnouchi; Alexander Hess; Olaf Michel; Shunkichi Baba; Toshiaki Yagi Background: Cisplatin (CDDP) is known to cause inner ear damage while carboplatin (CBDCA) induces less ototoxicity than CDDP. We examined apoptotic changes in the cochlea of guinea pigs after injection...