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Keywords: Ofloxacin
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Chemotherapy (1995) 41 (1): 34–38.
Published Online: 11 September 2009
...Daryl J. Hoban; Ronald N. Jones Ofloxacin, a newer fluorinated 4-quinolone having a broad spectrum of activity was evaluated against 5,553 clinical pathogens isolated from urine, respiratory tract, skin and genital tract infections at 18 Canadian Medical Centers spread across the nation...
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Chemotherapy (1994) 40 (1): 61–64.
Published Online: 11 September 2009
...Wu Ruanguan; Yan Kunming; Song Qiong A retrospective clinical study was conducted to evaluate the efficacies of various kinds of antibiotics on 804 patients with typhoid fever. Of 16 regimens studied, ofloxacin and enoxacin achieved 100 cure rates without relapse or carriage of Salmonella typhi...
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Chemotherapy (1995) 41 (2): 92–99.
Published Online: 11 September 2009
... and ofloxacin. The ‘killing rates’ were calculated in analogy to the growth rate. The bactericidal activity of the quinolones tested against E. coli was minimally influenced by the reduced generation time and the effect against S. aureus was moderate. As compared to their rapidly growing counterparts (g = 0.4 h...
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Chemotherapy (1994) 40 (5): 333–336.
Published Online: 11 September 2009
... or bacteriostatic effect cooperating with host defense mechanisms including polymorphonuclear neutrophils (PMNs). We investigated the effect of new quinolone antimicrobials on chemiluminescence (CL) response of human PMNs. Among many NQs, we chose ofloxacin, lomefloxacin, fleroxacin, sparfloxacin, AM-1155, NM-394...
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Chemotherapy (1997) 43 (5): 378–384.
Published Online: 11 September 2009
...Margaret Drehobl; Lawrence Koenig; Michael Barker; Patricia St. Clair; Dionigi Maladorno The efficacy and safety of 10 days’ oral treatment with fleroxacin 400 mg once daily were compared with those of ofloxacin 400 mg twice daily in adults with skin and soft tissue infections. The most common...
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Chemotherapy (1993) 39 (2): 120–123.
Published Online: 11 September 2009
... μg/ml. The frequency of one-step development of levoflox-acin-resistant CNS was < 1 x 10 –– 9 . After repeated transfer of CNS in the presence of increasing concentrations of levofloxacin or other quinolones, there were 4-fold increases in MIC 50 values for both levofloxacin and ofloxacin, whereas...
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Chemotherapy (1996) 42 (Suppl. 3): 20–23.
Published Online: 11 September 2009
... with a regimen containing rifabutin, isoniazid and at least three other susceptible drugs. Only 47% achieved a sustained sputum conversion. Four died during treatment due to disease progression. From March 1992 to July 1993, 17 cases of MDR-TB were treated with an ofloxacin-containing anti-TB regimen for 12-24...
Journal Articles
Chemotherapy (1996) 42 (Suppl. 3): 24–29.
Published Online: 11 September 2009
...Mangunnegoro Hadiarto; Aditama Tjandra; Achmad Hudoyo There is growing concern, even among developed countries, about the increasing incidence of multidrug-resistant tuberculosis (MDR-TB). Results are reported from a study investigating ofloxacin used in the treatment of 57 patients with MDR-TB...
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Chemotherapy (1996) 42 (Suppl. 3): 16–19.
Published Online: 11 September 2009
..., 6-month short-course chemotherapy for all newly detected smear-positive cases. The cure rate based on cohort analysis was 88% in 1993. Complete data are not available on resistance although the initial and acquired resistance rates were 28.1 and 41.1%, respectively. MDR-TB treated with ofloxacin has...
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Chemotherapy (1996) 42 (Suppl. 3): 10–15.
Published Online: 11 September 2009
... sensitive or not previously exposed anti-TB drugs. Duration of treatment for 24-30 months depends on severity, previous therapy and the number of drug resistances. Surgery is suggested for persistent positive cases with localized lesions and a good cardiopulmonary reserve. The quinolone, ofloxacin...
Journal Articles
Chemotherapy (1996) 42 (Suppl. 3): 2–9.
Published Online: 11 September 2009
... tuberculosis Drug resistance Ofloxacin Fluoroquinolones © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic...
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Chemotherapy (1991) 37 (Suppl. 1): 60–67.
Published Online: 10 September 2009
... tried both ofloxacin (OFX) treatment and a combination treatment with OFX and a single dose of aminoglycoside (isepamicin). Both groups showed the same cure rate on day 5, but the bacteriuria elimination rate on day 1 was slightly higher in the isepamicin-OFX group. The recurrence rate on days 7–14 did...
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Journal Articles
Chemotherapy (1991) 37 (Suppl. 1): 49–54.
Published Online: 10 September 2009
...L.E. Nicolle; J. Degelau; P. Alessi; J. Cullison; B. Meyers The efficacy and safety of ofloxacin for the treatment of pneumonia, urinary infection and skin infections in the institutionalized elderly is being studied in a multicenter North American trial. The two study arms include an open...