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Keywords: Methotrexate
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Chemotherapy (2011) 57 (3): 268–274.
Published Online: 06 June 2011
... evaluated the in vitro elution and flexural properties of Vertebroplastic™ and Confidence Ultra™ bone cements (Depuy Spine Inc., Raynham, Mass., USA) containing methotrexate. In vitro elution was measured by placing bone cement specimens containing 4 different methotrexate amounts in 20 ml saline...
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Chemotherapy (1993) 39 (4): 242–247.
Published Online: 11 September 2009
...Tawfeeg A.O. Najjar; Ibrahim M. Al Fawaz Plasma methotrexate (MTX) levels were measured in 10 children (age 3-12 years) who received a total of 43 infusions of MTX. The total dose (1,000 mg/m 2 ) was administered as a bolus of 200 mg/m 2 with 24-hour infusions of 800 mg/m 2 . The clearance was fast...
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Chemotherapy (1994) 40 (4): 227–231.
Published Online: 11 September 2009
...Abdel-Moneim M. Osman; Samir F. Saad; Sherif Y. Saad; Abdel-Bast A. El-Aaser; Mahmoud M.E. El-Merzabani The pharmacokinetics of two commonly used anticancer drugs, methotrexate (MTX) and 5-fluorouracil (5-FU), were investigated in normal and bilharzial-infested mice. Liver glu-cose-6-phosphatase...
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Chemotherapy (1994) 40 (6): 427–430.
Published Online: 11 September 2009
...S. Subramaniam; Shyama Subramaniam; M. Jagadeesan; Shyamala Devi Most of the breast cancer patients are treated with CMF which is a combination of three anticancer agents namely cyclophosphamide, methotrexate and 5-fluorouracil. The metabolites of CMF induce the level of lipid peroxides...
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Chemotherapy (1989) 35 (5): 363–372.
Published Online: 09 September 2009
... and methotrexate. Yet, PHA-stimulated cells proved 3- to 5-fold more sensitive to the cytotoxic effects of these drugs. The greater drug sensitivity of the PHA-stimulated cell line was associated with enhanced sodium-dependent methionine transport and altered amino acid transport systems. Differences...
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Chemotherapy (1987) 33 (4): 234–239.
Published Online: 09 September 2009
... and undernutrition are widely prevalent in India, the effect of initial nutritional status on the overall kinetics of methotrexate (MTX) administered to cancer patients appeared to be of practical importance. A study of 6 Indian children with malignancies was made to examine the pharmacokinetics of low dose MTX...
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Chemotherapy (1982) 28 (6): 480–501.
Published Online: 08 September 2009
... daunorubicin, cytosine arabinoside, vincristine, methotrexate, bis-chlorethyl-nitrosourea and chlorozotocin. After the cells were exposed for either 1 or 24 h to several concentrations of each drug, clear differences in suppressive effects were seen. The experimental applications of this technology...
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Chemotherapy (1982) 28 (3): 209–212.
Published Online: 08 September 2009
...M.P. Chitnis; S.S. Joshi; R.P. Gude; R.S. Menon The induction of complete resistance to adriamycin in L1210 leukaemia was accomplished after 10 transplant generations. The adriamycin-resistant subline showed cross-resistance to vincristine and bouvardin. It was sensitive to methotrexate...
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Chemotherapy (1975) 21 (1): 33–40.
Published Online: 25 May 2009
...T.K. Basu; D.C. Williams The effect of methotrexate on theNADPH-dependent hepatic microsomal drug-metabolizing enzymes of the normal rat has been investigated. Pre-treatment of the animals with methotrexate for 3 successive days resulted in significant increases in the activities of biphenyl...
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Chemotherapy (2009) 55 (2): 83–90.
Published Online: 15 January 2009
...Viswa Kalyan Kolli; Premila Abraham; Bina Isaac; Dhayakani Selvakumar Background: Nephrotoxicity is one of the adverse side effects of methotrexate (MTX) chemotherapy. The mechanism of renotoxicity of MTX is not fully understood. It is essential to understand the mechanism of nephrotoxicity of MTX...
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