...Natalia Maximova; Pasquale Fabio Calabrò; Alice Cangialosi; Antonello Di Paolo Introduction: High-dose methotrexate (MTX) is used to treat pediatric acute lymphoblastic leukemia (ALL). The drug has a low therapeutic index and a highly interindividual variability in systemic exposure...

... of 149 LR-GTN patients were enrolled in the affiliated Beijing Maternity Hospital of Capital Medical University from January 2014 to January 2017 and randomly divided into 3 groups with 50 cases in the methotrexate (MTX) group, 49 in actinomycin D (ACT-D) group, and 50 in ACT-D+MTX group. Follow-up...

...: The aim of this study was to determine the efficacy of an MMP-9/12 inhibitor, AZD3342, on tumor growth and GI toxicity in a rat model. Methods: Female tumor-bearing Dark Agouti rats ( n = 90) were divided into 4 groups: vehicle control; methotrexate (MTX); AZD3342, and MTX + AZD3342. Tumors were measured...

...Sandra Halwachs; Ingo Schaefer; Peter Seibel; Walther Honscha Background/Aims: Concurrent treatment with methotrexate (MTX) and enzyme-inducing antiepileptic drugs including phenobarbital (PB) reduces the efficacy of MTX chemotherapy in cancer patients. We have shown that Reduced folate carrier...

... evaluated the in vitro elution and flexural properties of Vertebroplastic™ and Confidence Ultra™ bone cements (Depuy Spine Inc., Raynham, Mass., USA) containing methotrexate. In vitro elution was measured by placing bone cement specimens containing 4 different methotrexate amounts in 20 ml saline...

...F. Ranchon; N. Vantard; A. Gouraud; V. Schwiertz; E. Franchon; B.N. Pham; T. Vial; B. You; F. Bouafia; G. Salles; C. Rioufol We report a case of a potential drug-drug interaction in a woman treated by a first injection of high-dose methotrexate for a T-lymphoblastic lymphoma. Valaciclovir...

...Abdel-Moneim M. Osman; Samir F. Saad; Sherif Y. Saad; Abdel-Bast A. El-Aaser; Mahmoud M.E. El-Merzabani The pharmacokinetics of two commonly used anticancer drugs, methotrexate (MTX) and 5-fluorouracil (5-FU), were investigated in normal and bilharzial-infested mice. Liver glu-cose-6-phosphatase...

...S. Subramaniam; Shyama Subramaniam; M. Jagadeesan; Shyamala Devi Most of the breast cancer patients are treated with CMF which is a combination of three anticancer agents namely cyclophosphamide, methotrexate and 5-fluorouracil. The metabolites of CMF induce the level of lipid peroxides...

...Tawfeeg A.O. Najjar; Ibrahim M. Al Fawaz Plasma methotrexate (MTX) levels were measured in 10 children (age 3-12 years) who received a total of 43 infusions of MTX. The total dose (1,000 mg/m 2 ) was administered as a bolus of 200 mg/m 2 with 24-hour infusions of 800 mg/m 2 . The clearance was fast...

...S.S. Hussain; M.H. Amer; M.A. Hannan Cytotoxicity of cisplatin and carboplatin was compared using each drug alone and in combination with either 5-fluorouracil (5-FU) or methotrexate (MTX) and with 5-FU, vincristine (VCR) and bleomycin (BLM) together in the mouse embryo fibroblast line C3H10T...

... and methotrexate. Yet, PHA-stimulated cells proved 3- to 5-fold more sensitive to the cytotoxic effects of these drugs. The greater drug sensitivity of the PHA-stimulated cell line was associated with enhanced sodium-dependent methionine transport and altered amino acid transport systems. Differences...

... and undernutrition are widely prevalent in India, the effect of initial nutritional status on the overall kinetics of methotrexate (MTX) administered to cancer patients appeared to be of practical importance. A study of 6 Indian children with malignancies was made to examine the pharmacokinetics of low dose MTX...

...M.G. El-Badawi; M.H. Amer; N.M. Dahaba; J.A. Fatani; D.M. Sabah; F.A. Mustafa Histological changes were studied in experimental animals following the intraperitoneal administration of high-dose cisplatin with or without high-dose methotrexate and citrovorum factor. There were pronounced renal...

... daunorubicin, cytosine arabinoside, vincristine, methotrexate, bis-chlorethyl-nitrosourea and chlorozotocin. After the cells were exposed for either 1 or 24 h to several concentrations of each drug, clear differences in suppressive effects were seen. The experimental applications of this technology...

...M.P. Chitnis; S.S. Joshi; R.P. Gude; R.S. Menon The induction of complete resistance to adriamycin in L1210 leukaemia was accomplished after 10 transplant generations. The adriamycin-resistant subline showed cross-resistance to vincristine and bouvardin. It was sensitive to methotrexate...

...T.K. Basu; D.C. Williams The effect of methotrexate on theNADPH-dependent hepatic microsomal drug-metabolizing enzymes of the normal rat has been investigated. Pre-treatment of the animals with methotrexate for 3 successive days resulted in significant increases in the activities of biphenyl...

...A. Miyakawa; M. Padarathsingh; S. Vadlamudi; A. Goldin Because of the limiting toxicity of adriamycin (ADR, NSC-123127) on repetitive administration [9], attention was focused in this study on combination chemotherapy, employing sequential and alternating schedules of ADR and methotrexate (MTX, NSC...

...L.C. Mishra; J.A.R. Mead The antitumor activity of dihydrohomofolate against L1210 and L1210/FR-8 leukemia was studied and found to be comparable to that of tetrahydrohomofolate. Pretreatment of mice with methotrexate. a potent inhibitor of dihydrofolate reductase, decreased the antitumor activity...

...K.G. Hofer The effect of methotrexate on 125 I-iododeoxy-uridine ( 125 IUDR) incorporation into the DNA of L1210 and L1210/MTX ascites cells was determined at different stages of tumor development. Methotrexate administration to drug sensitive L1210 cells during the early phases of tumor growth...

...Viswa Kalyan Kolli; Premila Abraham; Bina Isaac; Dhayakani Selvakumar Background: Nephrotoxicity is one of the adverse side effects of methotrexate (MTX) chemotherapy. The mechanism of renotoxicity of MTX is not fully understood. It is essential to understand the mechanism of nephrotoxicity of MTX...