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Keywords: Methioninase
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Journal Articles

Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing’s Sarcoma in a Patient-Derived Orthotopic Xenograft Model

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Subject Area:
Further Areas , Oncology , Pharmacology
Kentaro Miyake, Tasuku Kiyuna, Shukuan Li, Qinghong Han, Yuying Tan, Ming Zhao, Hiromichi Oshiro, Kei Kawaguchi, Takashi Higuchi, Zhiying Zhang, Sahar Razmjooei, Maryam Barangi, Sintawat Wangsiricharoen, Takashi Murakami, Arun S. Singh, Yunfeng Li, Scott D. Nelson, Fritz C. Eilber, Michael Bouvet, Yukihiko Hiroshima, Takashi Chishima, Ryusei Matsuyama, Shree Ram Singh, Itaru Endo, Robert M. Hoffman
Journal: Chemotherapy
Chemotherapy (2019) 63 (5): 278–283.
https://doi.org/10.1159/000495574
Published Online: 23 January 2019
... typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model. Methods: The ES PDOX models were previously established in the right chest wall. The ES PDOX models were randomized into 5...
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