.... aeruginosa, 22% of Klebsiella pneumoniae , 9% of Enterobacter cloacae , and 7% of Serratia sp. were multidrug resistant. 59% of A. baumannii clinical isolates were meropenem-resistant. A. baumannii isolates from the lower respiratory tract were the most susceptible, followed by urine clinical isolates...

... diminished susceptibility to imipenem while remaining susceptible to meropenem. All these isolates lacked OprD or showed a reduced expression of this porin. Susceptibility to meropenem was thus independent of the level of OprD expression, indicating that the antimicrobial could be taken up via an alternative...

...A. Ferrara; Dos Santos; M. Cimbro The ability of double and triple combinations of antimicrobials with different mechanisms of action, such as teicoplanin, meropenem, gentamicin and sparfloxacin, to achieve synergisms was investigated in vitro on some moderate-level gentamicin-resistant (MLGR: 8...

...R. Edwards; J. Brown; D. Greenwood The activity of meropenem was similar to that of imipenem against 88 clinical isolates of Bacteroides spp., including 28 non- fragilis strains. Four of the isolates were able to hydrolyse cephamycins or penems. Investigation of β-lactamases from these strains...

...E. Yourassowsky; M.P. Van der Linden; F. Crokaert Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae . The minimal inhibitory concentrations (MICs...

...W.G. Wade; P. Bishop The susceptibility of 106 oral bacteria to meropenem, a new carbapenem antimicrobial, penicillin V, tetracycline and metronidazole was assessed by an agar dilution method. Meropenem was the most effective of the antimicrobials, with all strains tested being inhibited at ≤1 mg/l...

...H. Nouda; E.T. Harabe; Y. Sumita; T. Okuda; M. Fukasawa The affinity of meropenem for various known types of β-lacta-mases and its stability to them were tested in comparison with other β-lactams, including imipenem. Meropenem exhibited a marked stability to all p-lactamases tested and was only...

...: The experiments were performed on two Pseudomonas aeruginosa isolates, one producing VIM-1 and the other producing VIM-2 metallo-β-lactamase. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) of imipenem and meropenem alone and combined with EDTA, time-kill curves, PAE...

...David Raveh; Amos M. Yinnon; Ellen Broide; Bernard Rudensky Background: Faced with the extended-spectrum β-lactamase (ESBL) pandemic, we compared the susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanate. Methods: 121...

... with the disk method was carried out on 1,533 isolates of gram-negative bacilli from urine, pus, body fluid and blood from hospitalized patients. Results: Seventeen percent of isolates were susceptible only to meropenem and either to piperacillin + tazobactam, to cefoperazone + sulbactam or to both. Eleven...

...Joseph L. Kuti; David P. Nicolau Background: Dosage recommendations for antibiotics in patients receiving continuous veno-venous hemofiltration (CVVH) should be based on pharmacodynamic requirements. For meropenem, this would be achieving appropriate time above the minimum inhibitory concentration...

... the in vitro effects of combinations of meropenem, cefepime, or piperacillin-tazobactam with ciprofloxacin against multidrug-resistant P. aeruginosa strains by the time-kill method. The results show that both the combination of two beta lactams with ciprofloxacin and three beta lactams with ciprofloxacin...

...G. Samonis; N. Thomakos; T. Liakakos; A. Macheras; D. Mandrekas; S. Kanavaki; D. Bafaloukos; S. Maraki Background: The study evaluated the effects of cefepime and meropenem on the gastrointestinal (GI) colonization of surgical patients by Candida albicans . Patients and Methods: Twenty adult...

... bacterial test strains were determined in an experimental system using an in vitro urinary bladder model. The MICs of gatifloxacin and meropenem for Pseudomonas aeruginosa strains were not homogeneous before exposure to the drugs. The MICs of the strains examined reflected only that of their dominant...

...P. Cornacchione; L. Scaringi; E. Capodicasa; K. Fettucciari; E. Rosati; R. Sabatini; C. Benedetti; P. Marconi; R. Rossi; A. Del Favero Meropenem, a new carbapenem antibiotic, was assessed to evaluate its effects on some functional parameters of human polymorphonuclear (PMN) and natural killer (NK...

...Fariborz J.R. Abadi; Davis E. Yakubu; T. Hugh Pennington The in vitro activity of meropenem was compared with those of penicillin, ampicillin, cefuroxime, cetriaxone, cefotaxime, rifampicin, chloramphenicol, sulphadiazine and ciprofloxacin against 121 British meningococcal isolates...