..., respectively: 180.9, 198.7, 482.0, 580.0 and 690.1 for chloroquine; 3.4,3.4,9.2,4.0 and 5.8 for mefloquine; 21.9,10.5,40.7, 40. land 48.7 for quinine; 136.7,58.8,116.4,29.4 and 95.4 for cycloguanil, and 48.3, 57.5, 47.4, 61.5 and 37.8 for pyrimethamine. Before cryopreservation they were 172.5, 141.5, 453.2...

... three schizonticidal drugs, chloroquine, mefloquine and quinine, using the modified in vitro microtechnique. Results showed that all the clones derived from Gombak A isolate were chloroquine-resistant with average IC 50 values ranging at 0.1377-1.0420 μ M (0.007-0.058 mefloquine activity), sensitive...

...D.E. Schwartz; G. Eckert; J.M.K. Ekue Because of the extremely long terminal elimination half-life of mefloquine it is practically impossible to measure quantitatively its urinary excretion after a single dose. Indeed, a correct estimation would require collection of urine over a period of several...

...M.D. Edstein; J.R. Veenendaal; R. Hyslop Concentrations of mefloquine in plasma and breast milk were measured in 2 women following the administration of one Lariam® tablet (250 mg mefloquine). The milk-to-plasma ratio of mefloquine based on the area under the plasma and milk concentration curves...

...N.S. Wang; X.B. Guo; Q.D. Liu; L.C. Fu; G.Q. Li; K. Arnold The oral single-dose pharmacokinetics and bioavailability of mefloquine (M) in combination with pyrimethamine (P) and sulfadoxine (S) from a single non-lacquered tablet (NL; M 250 mg, P 25 mg, S 500 mg) and two lacquered tablets (L; M 125...

...D.E. Schwartz; E. Weidekamm; I. Mimica; P. Heizmann; R. Portmann Fansimef® is a new antimalarial combination containing pyrimethamine, sulfadoxine and mefloquine in the weight proportions 1+20+10. It has been designed to fight plasmodia resistant to the presently used antimalarial drugs...

...E. Weidekamm; D.E. Schwartz; U.C. Dubach; B. Weber Fansimef® is a new oral schizonticide which contains pyrimethamine (P), sulfadoxine (S) and mefloquine (M) in a weight ratio of 1:20:10. This antimalarial combination is highly active against multi-resistant Plasmodium falciparum and in vitro...

...I. Mimica; W. Fry; G. Eckert; D.E. Schwartz 250 mg mefloquine was administered orally once a week for 21 consecutive weeks to 5 volunteers. Blood samples were collected just before administration of the next dose, and the unchanged drug and its metabolite, Ro 21-5104, were measured in the plasma...

...D.E. Schwartz; G. Eckert; D. Hartmann; B. Weber; D. Richard-Lenoble; J.M.K. Ekue; M. Gentilini Oral single dose kinetics of mefloquine was investigated in 16 male volunteers, 3 Caucasians and 13 African natives. Unchanged mefloquine (= M) and one of its metabolites (= MM) were measured...

.../A2 clones decreased their susceptibilities to 19, 41 and 28% whilst ST 12/F8, ST 85/B3 and ST 85/B3 clones showed increases of 6, 43 and 21%, respectively, against chloroquine, mefloquine and quinine after cryopreservation. Further results also indicated that GC/B4, GC/B7, GC/C10, ST 85/A5, ST 85/D3...