...Matthaios Papadimitriou-Olivgeris; Nikolaos Giormezis; Fotini Fligou; Apostolos Liakopoulos; Markos Marangos; Evangelos D. Anastassiou; Efthimia Petinaki; Kriton S. Filos; Iris Spiliopoulou Background: The aim of the present study was to identify risk factors for linezolid-nonsusceptible coagulase...

...Satoshi Fujii; Satoshi Takahashi; Shinki Makino; Yusuke Kunimoto; Hiromasa Nakata; Norimasa Noda; Koichi Sakurai; Atsushi Miyamoto Background: Vancomycin and linezolid therapies are associated with renal dysfunction and thrombocytopenia, respectively. Methods: We retrospectively investigated...

...Thomas Grüger; Thomas Schmidt; Norbert Schnitzler; Sabine Nidermajer; Kerstin Brandenburg; Josef Zündorf Background/Aims: In a recent phase III clinical trial on linezolid, more patients in the linezolid treatment arm acquired Gram-negative catheter-related bloodstream infections despite...

...Po-Liang Lu; Jann-Tay Wang; Chih-Jung Chen; Wan-Chin Chen; Tun-Chieh Chen; Yhu-Chering Hwang; Shan-Chwen Chang Background: Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people...

... Linezolid Abstract Background: In this investigation, the urine samples obtained in a single oral-dose pharmacokinetic study were examined for their bactericidal activity against a range of relevant urinary tract pathogens. Methods: Six healthy volunteers received a single oral dose of ten oral antibiotics...

...Are Naess; Kristin Stenhaug Kilhus; Tone W. Nystad; Steinar Sørnes Background: To examine whether linezolid, a new oxazolidinone antibiotic, has an effect on human polymorphonuclear leukocyte (PMN) function. Methods: Flow-cytometric techniques for the demonstration of PMN chemotaxis towards zymosan...

...Juan C. Rodríguez; José M. Ðlvarez; Isabel Escribano; Gloria Royo In our study, we aim to determine the existence of microorganisms that are heteroresistant to linezolid among Staphylococcus aureus clinical isolates in our setting between 1996 and 2002; during this period, linezolid was not used...

...: The antimicrobial activity of daptomycin was tested versus linezolid, vancomycin, and ampicillin (enterococci on ly), against pathogens from three different collections: (1) Uropathogens from hospitalized urological patients with complicated and/or hospital-acquired UTIs of the Urologic Clinic, Hospital St...

...A. García-Tapia; J.C. Rodríguez; M. Ruiz; G. Royo Background: The new challenges involved in the chemotherapy of tuberculosis make it necessary to find novel drugs, especially ones that are useful in the latent phase of the disease. Methods: We evaluated the activity of linezolid...

...Sofía Ballesta; Álvaro Pascual; Isabel García; Evelio J. Perea The effect of linezolid on the phagocytic and bactericidal functions of human polymorphonuclear neutrophils (PMN) against gram-positive cocci was evaluated. Preincubation (30 min; 37°C) of PMN with different concentrations of linezolid...