... was to investigate the additional effect of sulbactam on monotherapy with colistin, tigecycline and imipenem in experimental sepsis with carbapenem-resistant A. baumannii in mice. Methods: Sepsis was developed in 8- to 10-week-old BALB/c mice by an intraperitoneal injection of A. baumannii. Antibiotic was given...

.... Comparator drugs were ceftazidime and imipenem, i.e. antibiotics with known high and low endotoxin-liberating potential, respectively. As a parameter for biological responses to endotoxin, the release of proinflammatory cytokines (tumor necrosis factor-α, interleukin-1β) from monocytes/macrophages...

... (trimethoprim/ sulfamethoxazole) Doxycycline Enterococcus faecium Fusidic acid Gentamicin Imipenem Mupirocin Novobiocin Rifampin Streptomycin Taurolidine Teicoplanin Vancomycin M icrobiology Chemotherapy 1993;39:254-264 Walter H. Traub Birgit Leonhard Dierk Bauer Institut für Medizinische...

...Tom Bergan; Helge Michalsen; Anna Stina Malmborg; Svend Stenvang Pedersen; Tanja Pressler; Olav Trond Storrøsten; Birgitta Standvik The pharmacokinetics of imipenem (MK-787) and cilastatin (MK-791) were studied in 30 patients with cystic fibrosis (CF) receiving the drug for therapeutic purposes...

... to dicloxacillin the staphylococci were characterized by an increase in the number of crosswalls, rifampin produced thickening of the cell wall, but only minimal changes were induced by gentamicin. Intracellular electrondense aggregates were observed in P. aeruginosa after exposure to imipenem, tobramycin...

...Alev Gerçeker; Gülten Ötük Imipenem and amikacin, alone and in combination, were investigated for their postantibiotic effect (PAE) on Pseudomonas aeruginosa. Four clinical strains of P.aeruginosa in the logarithmic phase of growth were exposed for 1 h to antibiotics, alone and in combination...

...M. Dan; D. Zabeeda; F. Poch Serum levels and serum bactericidal activities of six antipseudomonal agents were studied comparatively in 60 patients. Single intravenous doses of gentamicin (1.5 mg/kg), piperacillin (4 g), ceftazidime (1 g), imipenem (0.5 g), aztreonam (1 g), and ciprofloxacin (200 mg...

...Alev Gerçeker; Gülten Ötük The in vitro activities of imipenem, aztreonam, piperacillin, ciprofloxacin and amikacin were tested by the microbroth dilution technique against 86 clinical isolates of Pseudomonas aeruginosa. Imipenem and ciprofloxacin were the most active agents against gentamicin...

...Max Gehrlein; Hermann Leying; Wolfgang Cullmann; Susanne Wendt; Wolfgang Opferkuch The comparison of a clinical Acinetobacter baumanii isolate (strain No. 4852/88) and its selected imipenem-resistant (IMR) clone exhibited a complex reorganization of the penicillin-binding proteins (PBPs...

... epidermidis .An agar dilution technique was used to determine the MIC 50 and MIC 90 of ALP 201 in comparison with cefotaxime, cefuroxime, clindamycin, imipenem, piperacillin, tobramycin and vancomycin. Overnight cultures were suspended to produce inocula of 10 5 colonies from a replicator. ALP 201 was shown...

...E. Yourassowsky; M.P. Van der Linden; F. Crokaert Phase contrast microscopy, killing curves and turbidimetric growth curves were used in a comparative study of the antibacterial effects of imipenem and meropenem on Haemophilus influenzae . The minimal inhibitory concentrations (MICs...

...Albert E. Yellin; Peter N.R. Heseltine; Thomas V. Berne; Maria D. Appleman; Mark A. Gill; Frank C. Chenella An open-label prospective study was performed employing intramuscularly administered imipenem as an adjunct to surgery in 20 patients with acute cholecystitis and 24 patients with perforated...

...Rob Roy MacGregor Imipenem is the broadest-spectrum antibiotic currently available but requires frequent intravenous dosing for efficacy. A recently formulated finely milled preparation can be given intramuscularly in small volumes and demonstrates kinetics favorable for 12-hourly intramuscular...

...Chatrchai Watanakunakorn The combinations of imipenem with gentamicin and imipenem with rifampin were studied by the time-kill method against 20 strains of methicillin-resistant Staphylococcus aureus .Twelve strains were resistant to imipenem, 18 resistant to gentamicin, 5 resistant to both...

...) + sulbactam (8 μg/ml), cefamandole (8 μg/ml), fosfomycin (4 μg/ml + 25 μg/ml glucose-6-phosphate), imipenem (8 μg/ml), netilmicin (4 μg/ml), trimethoprim + sulfamethoxazole (1/19 μg/ml) and vancomycin (1 μg/ml), respectively. Conversely, teicoplanin (1 μg/ml) combined with fusidic acid (0.5 μg/ml...

...W. Kern; H. Gulden; E. Vanek; E. Kurrle The antibacterial activity of imipenem combined with norfloxacin, ciprofloxacin, or ofloxacin against 43 gram-positive cocci and 53 aerobic gram-negative rods isolated from hospitalized patients was determined by the checkerboard method and compared...

... a more accurate and appropriate antibacterial therapy. The two drugs – ceftriaxone (Rocephin®) and imipenem plus cilastatin (Tienam®) – that have been taken into consideration in this study, having a similar antibacterial spectrum though with different kinetics, may have the same BQ values in bronchial...

...Ashir Kumar; Rosslyn Wofford-McQueen; Ralph C. Gordon For 16 isolates of Pseudomonas cepacia from patients with cystic fibrosis, synergism was determined by the killing curve method, utilizing various combinations of antibiotics [ticarcillin (Ti), rifampin (Ri), tobramycin (To), imipenem (Im...

...Walter H Traub; Dierk Bauer; Marlene Spohr Five antimicrobial drugs (ceftazidime, ciprofloxacin, imipenem, piperacillin and tobramycin) and two human, intravenously applicable, IgG immunoglobulin preparations (Psomaglobin®, Polyglobin N®) were examined alone and in various combinations...

...Christina Brattström; Anna-Stina Malmborg; Gunnar Tydén The penetration of imipenem into the human pancreatic juice following a single intravenous dose of 500 mg was investigated in five patients who had undergone pancreatic transplantation. With a special technique for segmental pancreatic...