... of type 2 herpes simplex virus. The 50% effective concentrations (EC 50 s) were 1-2 μ M . Acyclovir, which was run in parallel, had values of 4-28 μ M . Surprisingly, the compound was inactive against human cytomegalovirus. SP-303 was also virucidal at 50 μM. Interferon was not induced. The mode...

...M.R. Karim; M.I. Marks; D.C. Benton; W. Rollerson 277 5–7-day-old white Swiss mice were infected intranasally with Herpes simplex virus type 2 (HSV2) to mimic disseminated herpetic infection in human newborns. The antiviral efficacy of acyclovir, vidarabine and specific antiserum (SAS) alone...

...Richard S. Griffith; Donald C. DeLong; Janet D. Nelson In the studies conducted, arginine deficiency suppressed herpes simplex virus replication in tissue culture. Lysine, an analog of arginine, as an antimetabolite, antagonized the viral growth-promoting action of arginine. The in vitro data may...

... infectious doses which shortened survival time in comparison to the ascites tumor controls offered a good basis for chemotherapeutic studies. In these, treatments with IUDR (5-Iodo-2′-deoxyuridin) and Ara-A (9- β -D-Arabinofuranosyl-adenine), compounds with activity in infection with herpes simplex virus...

...Laura B. Talarico; Viviana Castilla; Javier A. Ramirez; Lydia R. Galagovsky; Mónica B. Wachsman The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23-trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative...