...Miriam E. Draenert; Reinhard Hickel; Yvette Draenert Purpose: The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant. Methods: The delivery of gentamicin of standardized samples was measured...

... and the presence of a synergistic effect with gentamicin (GM) against Escherichia coli strains. Antimicrobial activity was evaluated as a delay of the growth curve, using a turbidimetric method. E. coli ATCC 10798 and E. coli SC 12155 were employed as test micro-organisms in nutrient broth, and GM was used...

...George G. Zhanel; Sung O. Kim; Ross J. Davidson; Daryl J. Hoban; Lindsay E. Nicolle The effect of subinhibitory concentrations (1/8 x, 1/16 x, 1/32 x MIC) of ciprofloxacin or gentamicin on the adherence of Pseudomonas aeruginosa to Vero cells and voided uroepithelial cells was studied using two...

...Ana l. Vitas; Ramón Díaz; Carlos Gamazo Liposomes of the stable multilamellar type, which previously demonstrated great efficiency in antibiotic transport [Vitas et al: Antimicrob Agents Chemother 1996;40:146-151] were used in this study as carriers of gentamicin for treatment of mice lethally...

...Steen Christensen; Karin Ladefoged; Niels Frimodt-Møller Plasma concentrations of gentamicin following a fixed dose of 240 mg once daily to patients with normal renal function were measured. The purpose was to establish guidelines to achieve a sufficiently high peak concentration...

...A.F. Tawfik; M.A. Ramadan; A.M. Shibl The effect of subinhibitory concentrations of amikacin on Proteus mirabilis motility and adherence to human uroepithelial and to HeLa cells was compared with that of gentamicin. In addition, the effect of both antibiotics on cell surface hydrophobicity was also...

... to dicloxacillin the staphylococci were characterized by an increase in the number of crosswalls, rifampin produced thickening of the cell wall, but only minimal changes were induced by gentamicin. Intracellular electrondense aggregates were observed in P. aeruginosa after exposure to imipenem, tobramycin...

...R. Rohwedder; F. Bonadeo; M. Benati; Ojea Quintana; K. Schlecker; C. Vaccaro From 1983 until 1990 our standard antibiotic prophylaxis in colorectal surgery has been 80 mg gentamicin plus 500 mg metronidazole, both administered intravenously at the beginning of anesthesia, and then 80 mg gentamicin...

...M. Dan; D. Zabeeda; F. Poch Serum levels and serum bactericidal activities of six antipseudomonal agents were studied comparatively in 60 patients. Single intravenous doses of gentamicin (1.5 mg/kg), piperacillin (4 g), ceftazidime (1 g), imipenem (0.5 g), aztreonam (1 g), and ciprofloxacin (200 mg...

...Alev Gerçeker; Gülten Ötük The in vitro activities of imipenem, aztreonam, piperacillin, ciprofloxacin and amikacin were tested by the microbroth dilution technique against 86 clinical isolates of Pseudomonas aeruginosa. Imipenem and ciprofloxacin were the most active agents against gentamicin...

... (trimethoprim/ sulfamethoxazole) Doxycycline Enterococcus faecium Fusidic acid Gentamicin Imipenem Mupirocin Novobiocin Rifampin Streptomycin Taurolidine Teicoplanin Vancomycin M icrobiology Chemotherapy 1993;39:254-264 Walter H. Traub Birgit Leonhard Dierk Bauer Institut für Medizinische...

...A. Ferrara; Dos Santos; M. Cimbro The ability of double and triple combinations of antimicrobials with different mechanisms of action, such as teicoplanin, meropenem, gentamicin and sparfloxacin, to achieve synergisms was investigated in vitro on some moderate-level gentamicin-resistant (MLGR: 8...

...Chatrchai Watanakunakorn The combinations of imipenem with gentamicin and imipenem with rifampin were studied by the time-kill method against 20 strains of methicillin-resistant Staphylococcus aureus .Twelve strains were resistant to imipenem, 18 resistant to gentamicin, 5 resistant to both...

...R. Edwards; J. Brown; D. Greenwood The turbidimetric response to gentamicin of two strains of Escherichia coli was examined under aerobic and anaerobic conditions with 3 inocula. Turbidimetry showed that the minimum inhibitory concentration (MIC) was influenced by growth of partially inhibited...

...Kenneth J. Tack; L.D. Sabath Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under...

...Eduardo Malvino; Daniel Goldenberg; Rodolfo Giniger; Adriana Casabella; Miguel Jorge In order to avoid gentamicin toxicity trough serum concentrations when drug monitoring is not available, a correction factor for serum creatinine was calculated and evaluated. In a first group of 35 patients under...

...J.Y. Jacobs; Y. Wax; J. Michel; T. Sacks Mitomycin C, an antineoplastic antibiotic, and gentamicin showed a dose-related protective effect in mice against a lethal staphylococcal infection when used singly. A combination of these two drugs was shown to be synergistic in the mouse model. A specific...

...Mary L.S. Queiroz; N. Bathirunathan; G.E. Mawer Without treatment all mice died after receiving 10 3 Klebsiella pneumoniae by intraperitoneal injection. Nevertheless, it was possible to delay treatment for 12 h and still observe a therapeutic response from im gentamicin (5 mg/kg). This gave initial...

... prospectively evaluated the potential of nephrotoxicity in 90 infants and children (61 < 1 year and 29 > 1 year of age) receiving concomitant vancomycin and gentamicin for a duration of 3 to 38 (mean 9) days. Vancomycin and gentamicin doses ranged from 20 to 60 (mean 35) mg/kg/day and 2.5 to 14 (mean 6.5...

...Walter H. Traub; Marlene Spohr; Dierk Bauer Ampicillin, fusidic acid, gentamicin, imipenem, mezlocillin, ofloxacin, penicillin G, piperacillin, and vancomycin were examined for inhibitory and bactericidal activity in various broth media against 7 clinical isolates of Streptococcus faecalis...