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Keywords: Fleroxacin
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Journal Articles
Chemotherapy (1993) 39 (6): 386–389.
Published Online: 11 September 2009
...Hussain Qadri; Yoshio Ueno; Asif Ayub The in vitro activity of dual-acting antibacterial Ro 23-9424 was determined by the agar dilution method against 126 clinical isolates of Brucella melitensis . It was compared with fleroxacin, ciprofloxacin and five conventional drugs. MIC 50 and MIC 90 for Ro...
Journal Articles
Chemotherapy (1996) 42 (5): 354–362.
Published Online: 11 September 2009
...F. Fuentes; M.M. Martín; J. Izquierdo; M.L. Gómez-Lus; J. Prieto The present study investigates the postantibiotic effect (PAE) in vivo, and the postantibiotic subinhibitory concentration effects (PA-SE) in vitro and SE in vivo of three 4-fluoroquinolones (ciprofloxacin, fleroxacin and lomefioxacin...
Journal Articles
Chemotherapy (1995) 41 (5): 353–359.
Published Online: 11 September 2009
...Takao Yamamoto; Hisao Kusajima; Masaki Hosaka; Hirotaka Shinoda The uptake and intracellular activity of fleroxacin in murine J774.1 macrophages and human polymorphonuclear leukocytes were studied. The uptake of fleroxacin by J774.1 macrophages was rapid and reversible. The cellular...
Journal Articles
Journal Articles
Chemotherapy (1994) 40 (5): 333–336.
Published Online: 11 September 2009
... or bacteriostatic effect cooperating with host defense mechanisms including polymorphonuclear neutrophils (PMNs). We investigated the effect of new quinolone antimicrobials on chemiluminescence (CL) response of human PMNs. Among many NQs, we chose ofloxacin, lomefloxacin, fleroxacin, sparfloxacin, AM-1155, NM-394...
Journal Articles
Chemotherapy (1995) 41 (2): 92–99.
Published Online: 11 September 2009
... culture. By limiting the nutrient supply, generation times were lengthened from approximately 0.45 to 1.5 h up to 3.9 h. Three recent clinical isolates each of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were exposed to twice the MIC of ciprofloxacin, norfloxacin, fleroxacin...
Journal Articles
Chemotherapy (1993) 39 (5): 315–321.
Published Online: 11 September 2009
.... The following antibiotics were studied: loracarbef, cefixime, cefpirome, desacetylcefotaxime, cefpodoxime, cefmetazole, cefepime, cefprozil and fleroxacin. The synergy of two particular drug combinations was evaluated using cefpirome/desacetylcefotaxime and cefpodoxime/ desacetylcefotaxime. Cefpirome...
Journal Articles
Journal Articles
Journal Articles
Chemotherapy (1996) 42 (6): 468–472.
Published Online: 11 September 2009
...Michael Whitby; Lesley Angus; Graeme Nimmo; Vernon Hill The efficacy and safety of fleroxacin and ciprofloxacin were evaluated in a single-centre, prospective, randomised, blinded study of patients with complicated urinary infection in a spinal injury unit. Patients were randomised to receive oral...
Journal Articles
Chemotherapy (1996) 42 (Suppl. 1): 1–9.
Published Online: 11 September 2009
...K.G. Naber Fleroxacin is a new oral and intravenous trifluorinated 4-quinolone, which acts by inhibiting the essential bacterial enzyme DNA gyrase. Fleroxacin exhibits a broad spectrum of action, characterized by pronounced activity against aerobic gram-negative bacteria, but also against gram...
Journal Articles
Chemotherapy (1996) 42 (Suppl. 1): 33–42.
Published Online: 11 September 2009
.... The once daily dosage of fleroxacin [400 mg once daily intravenously (i.v.) for 2-4 days followed by oral doses of 400 mg for up to 10 days] was compared with twice daily ciprofloxacin (400 mg twice daily i.v. for 2-4 days followed by oral doses of 2 x 500 mg for up to 10 days) for treatment of inpatients...
Journal Articles
Chemotherapy (1996) 42 (Suppl. 1): 10–16.
Published Online: 11 September 2009
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Urinary tract infection Cystitis Bacterial cystitis Antibiotics Quinolones Fleroxacin ...
Journal Articles
Chemotherapy (1997) 43 (5): 378–384.
Published Online: 11 September 2009
...Margaret Drehobl; Lawrence Koenig; Michael Barker; Patricia St. Clair; Dionigi Maladorno The efficacy and safety of 10 days’ oral treatment with fleroxacin 400 mg once daily were compared with those of ofloxacin 400 mg twice daily in adults with skin and soft tissue infections. The most common...
Journal Articles
Journal Articles
Chemotherapy (1992) 38 (5): 308–318.
Published Online: 10 September 2009
...Yvette S. McCarter; Mary F. Mazens-Sullivan; Raymond C. Bartlett The in vitro activity of fleroxacin, a new trifluorinated quinolone was evaluated against 432 bacterial isolates. Fleroxacin was 1- to 2-fold less active than ciprofloxacin and at least as active as ofloxacin and lomefloxacin against...
Journal Articles
Chemotherapy (1992) 38 (3): 145–149.
Published Online: 10 September 2009
...R. Portmann; E. Weidekamm Fleroxacin concentrations in human and rat tissues were determined by HPLC following extraction with dichloromethane: isopropanol. This method yielded a high recovery of more than 85%. In the investigated tissues the fleroxacin levels were equal to or higher than those...
Journal Articles
Chemotherapy (1989) 35 (5): 360–362.
Published Online: 09 September 2009
...A. Kropec; F. Daschner The in vitro activity of the 4-quinolone compound fleroxacin (Ro-23–6240) was compared with that of enoxacin, ofloxacin, cefepime (BMY-28142), ceftazidime, ceftriaxone, and tobramycin against a total of 30 recent clinical isolates of Acinetobacter calcoaceticus subsp...
Journal Articles
Journal Articles