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Keywords: Excitatory amino acids
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Journal Articles
Biochemical and Clinical Aspects of Methotrexate Neurotoxicity
Available to Purchase
Journal:
Chemotherapy
Chemotherapy (2003) 49 (1-2): 92–104.
Published Online: 07 May 2003
... with changes in the brain and/or the spinal cord which may be progressive and even lead to coma and death in severe cases. It is believed that MTX can induce direct toxic effects to the CNS by damaging the neuronal tissue. Moreover, MTX interferes with the metabolic pathways of folates, excitatory amino acids...
