...Tatsuya Kodama; Keisuke Watanabe; Masaharu Shinkai; Takeshi Kaneko Background: T790M is a major cause of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance, but the clinical significance of T790M disappearance is unknown. Case Report: We report 3 cases of pulmonary...

... agents into standard neoadjuvant treatment of patients with LARC [ 5,6 ]. The biological agents that target the epidermal growth factor receptor (EGFR) or the vascular endothelial growth factor (VEGF) have been tested in the neoadjuvant setting due to their ability to specifically target cell signaling...

...Nobuyuki Koyama; Yasutaka Watanabe; Yuki Iwai; Rumi Kawamura; Chihiro Miwa; Yoshiaki Nagai; Koichi Hagiwara; Shinichiro Koyama Background: Exon 19 deletion (Del19) and exon 21 L858R substitution (L858R), which account for 90% of epidermal growth factor receptor ( EGFR ) mutations as common...

... was a 41-year-old woman who had never smoked and was diagnosed with stage IV adenocarcinoma of the lung with an epidermal growth factor receptor (EGFR) mutation. She was treated with afatinib for the recurrence of leptomeningeal metastases. After the treatment with afatinib was initiated, the neurological...

...Osamu Tetsu; Matthew J. Hangauer; Janyaporn Phuchareon; David W. Eisele; Frank McCormick Background: The discovery of mutations in epidermal growth factor receptor (EGFR) has dramatically changed the treatment of patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer deaths...

...Eun Joo Kang; Kyung Hoon Min; Gyu Young Hur; Sung Yong Lee; Jae Jeong Shim; Kyung Ho Kang; Sang Cheul Oh; Jae Hong Seo; Jun Suk Kim Background: Despite the development of molecular research and targeted therapy, patients with wild-type epidermal growth factor receptor (EGFR) non-small cell lung...

...Scott Chih-Hsi Kuo; Ping-Chih Hsu; Chih-Hung Chen; Chih-Teng Yu; Chih-Liang Wang; Fu-Tsai Chung; Shu-Min Lin; Yu-Lun Lo; Tse-Ching Chen; Chien-Ying Liu; Cheng-Ta Yang Background: First-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for the treatment...

..., instructions or products referred to in the content or advertisements. Docetaxel Erlotinib Non-small cell cancer Predictive factors Second-line therapy Epidermal growth factor receptor Lung cancer is the most common cancer and cause of cancer-related death in the world. A large fraction...