..., respectively: 180.9, 198.7, 482.0, 580.0 and 690.1 for chloroquine; 3.4,3.4,9.2,4.0 and 5.8 for mefloquine; 21.9,10.5,40.7, 40. land 48.7 for quinine; 136.7,58.8,116.4,29.4 and 95.4 for cycloguanil, and 48.3, 57.5, 47.4, 61.5 and 37.8 for pyrimethamine. Before cryopreservation they were 172.5, 141.5, 453.2...

...Hooi Hoon Ang; Chan Kit Lam; Mak Joon Wah Six clones were derived from each Plasmodium falciparum isolate obtained from Malaysia, Africa and Thailand and were characterized against type II antifolate drugs, cycloguanil and pyrimethamine using the modified in vitro microtechnique. Results showed...

...M.D. Edstein; J.R. Veenendaal; H.V. Scott; K.H. Rieckmann The pharmacokinetics of proguanil and its active metabolite, cycloguanil, were determined at steady-state in 6 healthy male volunteers after daily administration of 2 Paludrine® tablets (200 mg proguanil hydrochloride). A maximum plasma...

..., cycloguanil and pyrimethamine, before and after subculturing them in vitro for a period of 3 years, was studied. Methods: Thirty fresh clones were obtained from five different blood samples infected with P. falciparum isolates. They were tested for their susceptibility to the above drugs during...