...Li Wang; Kai Yang; Xinxin Xie; Hailiang Wei; Pengli Wang; Shaohui Wang Introduction: This study aims to evaluate the efficacy and safety of cryoablation combined with pembrolizumab treatment versus cryoablation alone in patients with advanced non-small cell lung cancer (NSCLC). Methods...

... effect of combining AKT (MK-2206) and MAPK kinase (AZD 6244) inhibitors in MARIMO cells. Methods: We detected the expression of phosphorylated AKT in MARIMO cells treated with inhibitors for 24 or 48 h by western blotting and analyzed cell proliferation, cell cycle, and apoptosis by flow cytometry. We...

... steroid molecule, mimics the activity of naturally occurring antimicrobial peptides. Methods: MICs and MBCs were determined using the microbroth dilution technique. Combinations were assessed using the checkerboard technique. The bactericidal activity of CSA-13 in combination with colistin was measured...

...O. Schiraldi; E. Sforza; F. Piaia A double-blind study on 72 adult patients affected by typhoid fever was done utilizing a new sulfa-trimethoprim combination (trimethoprim-sulfamethopyra-zine) versus the well-known combination trimethoprim-sulfamethoxazole. The dosage used for the new drug was 2...

...D. Kaplan Minimum bactericidal concentrations of salicylate, nicotinaldehyde singly, and in combination with nicotinic acid, or nicotinamide were determined for Staphylococcus aureus 79 and 80, and Escherichia coli 95, at inocula of 10 7 –10 2 . The bactericidal dose of salicylate was affected...

...R.N. Grüneberg; A.M. Emmerson Experiments have been performed using rifampicin (RIF) and tetracycline (TET) to establish whether the use of the combination prevents the emergence of bacterial resistance to either drug. Experiments were performed using repeated 4-hour cycles of exposure of large...

...U.J. Koch; K.P. Schumann; R. Küchler; H. Kewitz The effectiveness of sulfamethoxazole (SMZ; 13 patients), trimethoprim (TMP; 23 patients), and the combination of both (39 patients) in therapy for acute urinary tract infections after major gynecological operations has been studied. Plasma...

... in the combination with trimethoprim (TM). The inhibition zones are often smaller around discs containing the same amount of the components SDMO/TM as those with co-trimoxazole and the inhibitory concentrations needed are frequently 2–4 times higher, especially against gram-negative bacteria, such as Escherichia...

...H. Knothe 25 5 2009 Chemotherapy 22: 62-69 (1975) The Antibacterial Efficacy of Two Trimethoprim-Sulphonamide Combinations H. K nothe Hygiene Institute, University o f Frankfurt, Frankfurt/M. Key Words. Trimethoprim Sulfamethoxazol Sulfadimethyloxazol Combination MIC-values...

... of 800 mg SMZ alone or in combination with 160 mg trimethoprim (TMP). Plasma disappearance of SMZ is characterized by first order processes. Elimination half-lives average about 10 h for the total sulfonamide and about 8 h for the active fraction which represents almost exclusively the unchanged drug...

...A. Miyakawa; M. Padarathsingh; S. Vadlamudi; A. Goldin Because of the limiting toxicity of adriamycin (ADR, NSC-123127) on repetitive administration [9], attention was focused in this study on combination chemotherapy, employing sequential and alternating schedules of ADR and methotrexate (MTX, NSC...

.... The pharmacokinetic characteristics of the resulting plasma levels lie with few deviations in the normal ranges observed in healthy adults. The content of active SMZ and TMP in the bile is of an order providing very favourable conditions for a curative effect of the combination in cases of biliary infections caused...

...F.H. Kayser; J. Wüst The validity of the disc diffusion method with a combined disc in determining bacterial resistance to trimethoprim/sulphamethoxazole (TMP/SMZ) has been investigated. With a 25- μ g disc containing 1 part of TMP and 19 parts of SMZ, a strong correlation between ‘minimal...

... diseases (46%). EMB was combined with one or two efficient drugs that could be applied. Therapeutic results were assessed in all patients whose therapy lasted at least 4 months (4–21 months, average 8 months). Patients who excreted tubercle bacilli were rendered negative. Negativity was obtained sooner...

...D. Münnich Treatment with TMP/SMZ was clinically successful in 96% of our 54 gastroenteritis cases to non-typhoid Salmonellae (34 showing a positive bacteriological test), whilst the bacteriological efficacy was only about 50%. A combined course TMP/SMZ plus polymyxin B has been effective both from...

...H. Knothe The effect of the combination preparation TMP/SMZ on the alimentary flora of human subjects was investigated at different doses. Following the short-term administration of the preparation, E. coli was particularly markedly reduced at doses as low as one tablet a day. The other alimentary...

...H. Nolte; H. Büttner Trimethoprim is absorbed well in man. Plasma peak levels between 0.9 and 1.9 μ g/ml are reached within 2–4 h after ingestion of 160 mg TMP alone or in combination with 800 mg SMZ. Plasma disappearance of TMP is characterized by first order processes. Elimination half-lives...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Penicillin Gonorrhoea Comparison Combination Probenecid MIC Clinical Report Chemotherapy 18: 262-268 (1973) A Comparison between Pivampicillin, Ampicillin and Penicillin G...

... Combination Acute brucellosis Synergism Chemotherapy 16: 332-335 (1971) Trimethoprim-Sulfamethoxazole Combination in the Treatment of Acute Human Brucellosis G. Giunchi, F. de R osa and F. Fabiani 1st Clinic for Infectious Diseases, University of Rome, Rome Abstract. Nine patients with acute...

...Kathrine Dornbusch Analysis of regression lines, i.e. the relationship between the zone of inhibition of bacterial growth around drug-impregnated discs and minimal inhibitory concentration for the same drug in agar, have been used to illustrate the synergistic effect of the combination trimethoprim...