... adherence to cell surfaces may be a criterion in selecting antibiotics for therapy. This study was performed in order to investigate the activity of amoxicillin, chloramphenicol, and clarithromycin in modifying the adhering activity of Bordetella pertussis to human epithelial cells. The actions...

... to children once daily in a dose of 100 mg/kg/day. Patients in group II received ampicillin 160 mg/kg/day and chloramphenicol (AMCL) 100 mg/kg/day (i.v. to adults and i.m. to children) every 6 h. No significant difference was observed between the two therapeutic regimens with regard to mortality, time taken...

...Giuseppe Morelli; Modestino Guerriero; Pasquale Cristiano; Patrizia Galderisi; Attilio Postiglione; Franco Paradisi The authors have conducted an open randomized study to compare the clinical efficacy and safety of cefoperazone with those of chloramphenicol in the treatment of typhoid fever...

...Milap C. Nahata Chloramphenicol serum concentration is often monitored to assure efficacy and prevent toxicity. We studied the relationship between steady-state chloramphenicol serum concentration and hematologic adverse effects in 45 pediatric patients. The mean peak serum concentration...

...T. Sicilia; E. Estévez; A. Rodríguez A comparative study was made of the penetration of fosfomycin, penicillin G, ampicillin and chloramphenicol into the cerebrospinal fluid of patients with meningitis treated with combinations of fosfomycin and one of the other three antibiotics. Minimal...

... isolates were susceptible to chloramphenicol and tetracycline, but the indole-negative isolates varied in their susceptibility to these antibiotics. Whereas there was no relationship between indole production and susceptibility to cephalothin among the K. pneumoniae isolates studied, it appeared...

... of erythromycin is also adversely affected by magnesium ions. P. aeruginosa cells, washed and suspended in isotonic phosphate buffer containing ascorbic acid, became increasingly susceptible to the action of polymyxin, erythromycin, chloramphenicol, neomycin and tetracycline. It is suggested that ascorbic acid...

...Elizabeth A. Jurek; Leonard B. Weiner; Paul A. Granato The in vitro activity of rosoxacin was compared to that of ampicillin, cefoxitin, chloramphenicol, and rifampin, against 94 clinical isolates of Haemophilus influenzae .The results indicated that rosoxacin had significantly better in vitro...

...Madhu B. Bansal; Vinod K. Dhawan; Haragopal Thadepalli The antimicrobial efficacy of BU-2313B, a new antibiotic, was evaluated in comparison with clindamycin, chloramphenicol and cefoxitin against 265 clinical anaerobic isolates. BU-2313B inhibited 88% of 66 isolates of Bacteroides fragilis tested...

...W.S. Ng; P.Y. Chau Chloramphenicol and thiamphenicol were tested by the agar dilution method against 105 Salmonella typhi , 15 S. paratyphi A, 6 S. paratyphi B, 8 S. paratyphi C , 57 Haemophilus influenzae and 60 Neisseriagonorrhoeae strains. The two drugs showed similar in vitro activity against...

...G. Allegri; E. Lucidi; G. Marca; E. Borgogelli The effects of chloramphenicol (CAP) and thiamphenicol (TAP) on the outcome of Chlamydiapsittaci infection in chick embryos were compared. CAP administered along with Chlamydia reduced embryo mortality rates but showed no appreciable effects when its...

...J. Vácha; M. Pospíšil; V. Velčovský Mice irradiated with a dose of 4.78 Gy X-radiation were treated 3 or 5 days with a thrice-daily dose of chloramphenicol of 160 or 320 mg/kg. Observation of the incorporation of 59 Fe into the heme fraction suggested that chloramphenicol has a depressive effect...

...R.R. Whitney; R.J. McRipley; H.H. Gadebusch Procedures for evaluating the efficacy of chemotherapeutic agents in an infant rat model of Haemophilus influenzae meningitis were developed. The results of efficacy studies with ampicillin, chloramphenicol, cefamandole, cefoxitin, and SQ 13,426 were...

...Francis O’Grady; Neil J. Pearson; Christine Dennis Chloramphenicol is bacteristatic for most species but bactericidal for Haemophilus influenzae and Neisseria meningitidis. Despite its generally lower activity, thiamphenicol exhibited equal or greater activity against these two species than did...

...R.C. Gordon; K.J. Tack; R.I. Haddy; L. Fechner; R. Wofford The comparative in vitro activity of amikacin, cefamandole, cefoperazone, cefotaxime, cefoxitin, cephalothin, chloramphenicol, moxalactam, piperacillin, ticarcillin and tobramycin against 170 community blood culture isolates of gram...

... fully susceptible to beta-lactam antibiotics, tetracycline, erythromycin and clindamycin. Anaerobic bacteria Antibiotic susceptibility Penicillins Cephalosporins Tetracycline Chloramphenicol Erythromycin Clindamycin Metronidazole © 1984 S. Karger AG, Basel 1984 Copyright / Drug Dosage...

...A. Meulemans; D. Henzel; M. Brun-Pacaud; J. Mohler; P. Vicart; Tran Ba Huy In vivo electrochemical detection of chloramphenicol in rat cortex was investigated with microelectrodes after intravenous injection of chloramphenicol succinate (170 mg·kg -1 ). A classical pharmacokinetic study with high...

... and meningitis revealed that TMP/SMZ penetrated well into the cerebrospinal fluid (CSF) and that 37% of serum levels were achieved. The efficacy of TMP/SMZ was compared with that of ampicillin, chloramphenicol, cefotaxime and lamoxactam. Bacterial clearance from blood and CSF was significantly greater with TMP...

...Walter H. Traub; Paula I. Fukushima Several clinical isolates and O-antigen reference strains of Serratia marcescens were shown to yield spontaneously phenotypic variants with nonspecific, combined resistance or decreased susceptibility for chloramphenicol, nalidixic acid, nitrofurantoin...

... by suppression of parasitaemia and extension of survival period. Of these, demeclocycline, tetracycline and oxytetracycline were effective only at high dose level. Chloramphenicol, erythromycin and gentamicin were relatively inactive. Treatment in 5- to 6-day-old established infection of chicks has shown...