...Eva Susanne Dietrich; Ute Bieser; Uwe Frank; Guido Schwarzer; Franz D. Daschner The efficacy of ceftriaxone versus other cephalosporins in the perioperative prophylaxis of surgical wound, urinary tract and respiratory tract infections was compared in a meta-analysis of randomized controlled trials...

...Manoucher Dezfulian; Roger A. Bitar; John G. Bartlett The in vivo activity of ceftriaxone was examined in an experimentally induced subcutaneous infection involving Bacteroides fragilis and Escherichia coli. Mice were challenged with 1 of 10 strains of B. fragilis or E. coli, or a dual combination...

... can prevent slime production. In this paper we report the results of a prospective study involving 100 shunt operations. The objective was to evaluate the efficacy of a single preoperative dose of ceftriaxone (2 g, i.v.) in preventing shunt infection. Ceftriaxone was chosen for its pharmacokinetic...

... of a prospective study with 170 renal transplant patients, undertaken to evaluate the efficacy of ceftriaxone in the prevention of wound and early urinary tract infection. No wound infection was observed, however, 12 patients (7.1%) developed urinary tract infections. On the basis of these data, we recommend...

...Zhu Zhu; Ai-Xia Wang; Yan Li The pharmacokinetics of ceftriaxone were studied in 5 healthy Chinese volunteers who received single doses of 1 or 2 g by intravenous infusion at 2-weekly intervals. Only 50 μ1 of plasma was required for the determination of plasma ceftriaxone concentrations using...

...Patrick J. Van Reempts; Bart Van Overmeire; Ludo M. Mahieu; Karel J. Vanacker The safety of ceftriaxone has been evaluated in 80 neonates who were treated empirically for suspected infection with either ceftriaxone and ampicillin (group A, age 0-72 h) or ceftriaxone and vancomycin (group B, age...

...F. Scaglione; S. Dugnani; G. Demartini; M.M. Arcidiacono; C.E. Cocuzza; F. Fraschini The in vitro efficacy of ceftriaxone plus amikacin combination against gram-positive and gram-negative bacteria, clinically isolated from patients affected by pneumonia in intensive care units, was compared...

... within 3 months. Their good safety profiles and relatively lower costs were very cost-effective for treatment of typhoid fever, and they can be recommended as the first-line choices for routine management of this disease. In addition, our results suggested that ceftriaxone treatment of typhoid fever...

...G. Hotz; J. Novotny-Lenhard; M. Kinzig; F. Soergel The clinical efficacy of short-term antimicrobial prophylaxis with either one shot of ceftriaxone (1 g) or a course of 3 injections of a fixed combination of mezlocillin (2 g) and oxacillin (1 g) administered over 24 h was studied in a prospective...

... empirically treated with ceftriaxone and amikacin in a single daily dose. 96/183 (52%) patients had absolute granulocyte count lower than 100/mm3 at the onset; 68 (37%) were affected by acute leukemia or lymphoma, 3 (1 %) by chronic leukemia, 94 (51 %) by solid tumors, and 21 (11%) patients underwent bone...

...Franco Leoni; Stefania Ciolli; Anna Pascarella; Rosa Fanci; Roberto Caporale; Pier Luigi Rossi Ferrini Results of antibiotic treatment in 144 febrile episodes during drug-induced granulocytopenia are reported. 63 episodes were treated with ceftazidime plus amikacin and 81 with ceftriaxone (CFX...

..., but this does not allow adequate antibiotic levels in maternal blood and tissue to be achieved at the stage of incision and during surgery. We evaluated by bioassay maternal and fetal serum and placental ceftriaxone concentrations following the intravenous administration of 1.0 g of ceftriaxone upon...

..., for 2 days postoperatively; group B, ornidazole 1 g by intravenous infusion plus ceftriaxone 2 g i.v. 2 h before surgery and the same doses of the drugs per 24 h for 2 days postoperatively. Wound infection occurred in 1 case of group A versus 2 cases of group B (p > 0.25). Ornidazole plus ceftriaxone...

... was ceftriaxone because of its broad range of activity, safety, and once-daily administration. Two hundred and ninety cases of outpatient ceftriaxone usage were recorded between January 1989 and March 1990. Ceftriaxone was found to be most useful for bone, soft tissue, and gynaecological infections. Not only...

...John S. Bradley Parenteral ceftriaxone was administered as a once-daily outpatient treatment to a selected low-risk population of neonates, infants, and children with moderate to severe bacterial infections. No incidences of treatment failure were seen in 200 children with uncomplicated infections...

...Angela Gutensohn; Donna Bunz; Luciana Frighetto; Peter Jewesson A two-stage intervention programme was performed to enable the effective substitution of ceftriaxone for cefotaxime in a teaching hospital with large numbers of transient prescribers. One hundred and sixteen patients with a variety...

...% post-policy, due largely to increased use of the longer-acting cephalosporins ceftriaxone and cefotetan. A 23% reduction in antibiotic acquisition costs was achieved over the 3-year period of the study, without detrimental effects on patient outcome. © 1991 S. Karger AG, Basel 1991 Copyright...

...Richard Brown We conducted a retrospective clinical evaluation to assess the efficacy of a 1-gram once-daily regimen of intravenously administered ceftriaxone in the treatment of a variety of bacterial infections. Of the 250 patients studied, 167 had infections of the lower respiratory tract...

... the application of once daily drugs, such as ceftriaxone, netilmicin or amikacin. For single dose treatment (1st day two applications), we used ceftriaxone in combination with netilmicin or amikacin as the first approach and retrospectively evaluated 47 patients for efficacy and safety. 10 9 2009 ©...

...D. Bassetti; M. Cruciani; M. Solbiati; F. Rubini; L. Gandola; G. Valenti; M. De Palma; R. Corda; N. Carimeo Seventy-two hospitalized patients with pneumonia or bacteremia were randomly allocated to receive ceftriaxone 2 g once daily i.v. or ceftazidime 2 g twice a day i.v. At the end of the study...