... therapeutic concentrations of cefotaxime (CTX). Results: In most cases, there was a moderate increase in CTX resistance (twofold to threefold), except in one strain which displayed a 16-fold increase in the minimum inhibitory concentration (MIC) of CTX after incubation in the serum. That strain showed...

...S.F. Yeo; Y.F. Chiew; C.P. Fung The in vitro activities of cefaclor, cefetamet, cefixime, cefotaxime and cefuroxime were determined against 150 isolates of Haemophilus influenzae . These included 50 ampicillin-susceptible, 50 β-lactamase-producing and 50 intrinsically ampicillin-resistant isolates...

...R. Rule; H. Buschiazzo; M. Rubio; G. Quiroga; P. de Buschiazzd Concentrations of cefotaxime in serum and tissue fluid were studied in the bovine after intravenous and intramuscular administration at a dosage of 10 mg • kg -1 body weight. Steers implanted subcutaneously with tissue cages were used...

... to in the content or advertisements. Ro 23-9424 In vitro activity Fleroxacin Brucella Cefotaxime M icro b io lo gy Chemotherapy 1993;39:386-389 S.M. Hussain Qadri Yoshio Ueno AsifAyub King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia Anti-Brucella Activity of Ro 23-9424...

... of fosfomycin were compared with ciprofloxacin, cefotaxime and pristinamycin. Pretreatment of S. aureus for 10 min with 4 × MIC of fosfomycin and ciprofloxacin clearly sensitized the bacteria to leukocytic killing in the presence of normal human serum (10% v/v); cefotaxime and pristinamycin failed to enhance...

...Angela Gutensohn; Donna Bunz; Luciana Frighetto; Peter Jewesson A two-stage intervention programme was performed to enable the effective substitution of ceftriaxone for cefotaxime in a teaching hospital with large numbers of transient prescribers. One hundred and sixteen patients with a variety...

...Ashir Kumar; Kenneth J. Kelly In vitro activity of cefixime, an experimental oral third-generation cephalosporin and 7 other antimicrobials (ampicillin, augmentin, trimethoprim/sulfamethaxa-zole, cefamandole, cefotaxime, cefuroxime, and cefaclor) were determined for 150 isolates of Haemophilus...

... $ 2.75/0 Clostridium perfringens Type A Comparison of in vitro and in vivo Activity of Twelve Antimicrobial Drugs Walter H. Traub Institut für Medizinische Mikrobiologie und Hygiene, Universität des Saarlandes, Hotnburg/Saar, FRG Key Words. Antibiotic susceptibility Cefamandole Cefazolin Cefotaxime...

...J. Unowsky; J. Saltier; I.H. Patel Ceftriaxone and cefotaxime are third-generation cephalosporins with similar in vitro potencies and spectra. However, previous studies have shown that ceftriaxone had superior in vivo activity (mouse PD 50 values > 2-fold lower) compared to cefotaxime in 23...

...C. Regamey Two of the 3rd generation cephalosporins, ceftriaxone and cefotaxime, have an almost identical antibacterial spectrum, but completely different pharmacokinetics. After an intravenous dose of 1 g, peak levels of both cephalosporins were > 100 μg/ml. Cefotaxime levels fall rapidly...

... antagonism of cefoxitin against another β -lactarn, cefotaxime, was examined in infected granuloma pouch of rats, cefoxitin antagonized the antibacterial activity of cefotaxime administered at 4 and 6 h after cefoxitin (cefoxitin levels in pouch exudate were around 5 μ g/ml). The antagonism of an enzyme...

...Ashir Kumar; Chang H. Kim In vitro activity of cefpimizole, an experimental third generation cephalosporin, and 10 other antimicrobials (ampicillin, azlocillin, cefamandole, cefoperazone, cefotaxime, mezlocillin, moxalactam, piperacillin, rifampin and sulfamethoxazole/trimethoprim) were determined...

...J.M. Wilson; P.A. Hunter Cefotaxime has extremely low MIC values in comparison with amoxycillin against Enterobacteriaceae , but studies of antibacterial activity using turbidimetric and viable count methods show no advantage for cefotaxime. Superior rates of killing have been demonstrated...

...Walter H. Traub Two in vitro β -lactam antibiotic (oxacillin, cefotaxime) ‘tolerant’ (MBC:MIC ratios = > 32) strains of Staphylococcus aureus served to intraperitoneally infect cyclophosphamide-pretreated (leukopenic) NMRI mice. With larger bacterial in-ocula (approximately 5 × 10 8 CFU) neither...

...T. Karachalios; G.P. Lyritis; E. Hatzopoulos In a study of 200 patients scheduled for orthopedic surgery, prophylaxis with either ceftriaxone or cefotaxime was equally effective. No patient developed bacterial infection, either systemic or local, during the first 10 postoperative days. In the 1...

...Mark A. Pierce; Ann M. Elliott; Glenn Cobbs Minimum inhibitory concentrations and minimum bactericidal concentrations were determined for cefotaxime, gentamicin, tobramycin and amikacin and for the combination of cefotaxime and each of the aminoglycosides in vitro against 200 strains...

...Hans Christian Korting; Dietrich Abeck The highest minimum inhibitory concentrations of ceftriaxone and cefotaxime in 89 analysed Neisseria gonorrhoeae isolates amounted to 0.008 and 0.031 μg/ml, respectively. In a randomized controlled trial the single intramuscular injection of ceftriaxone 250 mg...

...Rainer Ansorg; Christian-Alexander Primavesi; Gottfried von Recklinghausen Using a broth microtiter dilution method, minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) were determined for the aminothiazolyl cephalosporins cefpirome and cefotaxime against 436 blood culture...

...F. Fraschini; F. Scaglione The aim of this research was to collect precise data on the antibacterial activity of ceftriaxone and cefotaxime in the respiratory tract. The diffusion into pulmonary tissue and bronchial secretion and the antibacterial activity of the two antibiotics were evaluated...

...P. Barradas; M. Zamith; W. Videira; T. Cardosa; R.A. Marques; R. Avila The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin TM ) and cefotaxime in treatment...