... of moxifloxacin in calves, after intravenous, intramuscular and subcutaneous administration of a single dose. Meanwhile, plasma protein binding and bioavailability of moxifloxacin were also estimated. Methods: Plasma concentrations of moxifloxacin were measured using a modified HPLC method, and the extent...

.... Bioavailability Cytotoxicity Estradiol Etoposide Lung cancer Experimental Chemotherapy Chemotherapy 2010;56:32 38 DOI: 10.1159/000287354 Received: June 5, 2009 Accepted after revision: August 17, 2009 Published online: February 24, 2010 Effects of 17 -Estradiol on the Cytotoxicity of Etoposide in a Lung...

...Anna-Stina Malmborg Two derivatives of doxycycline, the monohydrate-free base and the hydrochloride salt were given orally to 12 volunteers in a crossover study. There was no difference in absorption and bioavailability between the two preparations. Secondary plasma peaks indicating reabsorption...

...Tom Bergan; Elisabeth Arnold A cross-over study on metronidazole was carried out with 10 healthy adult volunteers who received tablets (250, 500 and 1,000 mg) and suppositories (500, 1,000 and 2,000 mg). The bioavailability of the suppositories was approximately 90% of the corresponding tablet dose...

...Jan Sjövall; Douglas Westerlund; Gunnar Alván; Lennart Magni; Carl Erik Nord; Jörgen Sörstad The relative bioavailability of bacampicillin hydrochloride, a pro-drug of ampicillin, was compared after rectal and oral administration. Bacampicillin was administered rectally as a microenema. The oral...

... was correlated to β-lactamase inducibility of the test strains insofar as drugs acting as good or moderate enzyme inducers were ineffective in vivo. The combined therapy of mezlocillin with cefotaxime was effective in this case. This result was also correlated to the bioavailability of the β-lactams in infected...

...R. Delsignore; C.M. Baroni; G. Crotti; F. Mineo; U. Butturini; V. Ascalone; M. Cisternino The disposition and bioavailability of ceftriaxone, a novel cephalosporin, was studied in 7 healthy volunteers after a single 1.5-gram intramuscular administration in comparison with the same dose given...

..., with an average bioavailability of 37% in relation to the intravenous bioavailability, as evaluated by means of the accumulative renal excretion. 5 8 2009 © 1977 S. Karger AG, Basel 1977 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

.... There was a 21-fold increase in the relative bioavailability of PLG-encapsulated streptomycin compared with intramuscular free drug. In Mycobacterium tuberculosis H 37 Rv infected mice, eight doses of the oral streptomycin formulation administered weekly were comparable to 24 intramuscular injections of free...

...Lucyna Konieczna; Aleksandra Chmielewska; Henryk Lamparczyk The pharmacokinetics of orally administered ciprofloxacin and ofloxacin were studied in healthy volunteers to assess the influence of sex on drug bioavailability. The first group of subjects (9 males and 9 females) received a single oral...

...C. Perret; B. Lenfant; E. Weinling; D.H. Wessels; H.E. Scholtz; G. Montay; E. Sultan Background: This two-way, randomized, single-dose, crossover study determined the pharmacokinetics and absolute oral bioavailability of telithromycin in young and elderly healthy subjects. Methods: Twelve young (18...

.... Gastrointestinal mucosal damage from cytostatic treatment was estimated by WHO toxicity scores. No correlation was found between the degree of gastrointestinal damage and the presumed bioavailability of co-trimoxazole as estimated from serum levels of trimethoprim and sulphamethoxazole. The serum concentrations...