...Mínguez Mínguez; J.E. Lima; M.T. García; J. Prieto The aim of this work was to measure the susceptibility of Candida albicans pretreated for 2 or 6 h with fluconazole (Flu), ketoconazole (Ktz), amphotericin B (AmB) and 5-fluorocyto-sine (5-Fc) to the fungicidal action of human polymorphic...

...Reeta T. Mehta; Teresa J. McQueen; Afsaneh Keyhani; Gabriel López-Berestein Liposomal amphotericin B (L-AmB) is emerging as one of the most attractive new antifungal agents. We have attempted to show that phagocytic cells circulating in blood play an important role in transport and accumulation...

... B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole, JAI-amphotericin B (water-soluble compound), hamycin and amphotericin B combined with 5-fluorocytosine, using antibiotic medium M3, high-resolution broth (pH 7.1), Sabouraud’s dextrose, and yeast-nitrogen broth media (1 ml/tube...

...F. Mínguez; J.E. Lima; M.T. García; J. Prieto This study evaluates the influence of both fresh and heated human serum on the postantifungal effect (PAFE) induced by different concentrations of amphotericin B (AmB), 5-fluorocytosine (5-Fc), Ketoconazole (Kz) and fluconazole (Flu) on two strains...

...Heide Dermoumi The in vitro activity of itraconazole, fluconazole and amphotericin B was tested against 207 yeast strains and 3 Aspergillus fumigatus strains isolated from blood. The other 42 A. fumigatus strains were selected from respiratory tract infections. A microdilution method was employed...

... antifungal chemotherapy with a total dose of 2.2 g of amphotericin B. 11 9 2009 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any...

...A.S. Sekhon; A.A. Padhye; A.K. Garg; Z. Hamir Twenty-eight pathogenic isolates, 4 each of Candida albicans, C. lusitaniae, C. parapsilosis, Cryptococcus neoformans, Torulopsis glabrata and Trichosporon beigelii were tested for their in vitro sensitivity to amphotericin B (AmB), hamycin (HA...

...Giulia Morace; Stefania Manzara; Giuseppe Dettori The in vitro activity of fluconazole was tested against 13 yeast species (119 strains) isolated from clinical specimens during a 3-month period. For comparative purposes, three other antifungal compounds (5-fluorocytosine, amphotericin B...

... for 35 days was started 3 days after infection. The animals were treated with oral or parenteral itraconazole and fluconazole, 5 and 10 mg/kg, alone or in combination, 5 mg/kg + 5 mg/kg, or with itraconazole, 5 mg/kg, combined with parenteral flucytosine, 10 and 40 mg/kg, or parenteral amphotericin B...

...D. Caillot; R.O. Casasnovas; E. Solary; P. Chavenet; B. Bonnotte; A. Bonnin; B. Cuisenier; J.F. Couaillier; J.P. Kistermann; H. Guy Amphotericin B is commonly used as prophylactic therapy in addition to broad-spectrum antibiotics in febrile neutropenic patients with leukaemia. Despite amphotericin...

...J.W. van’;t Wout Treatment of fungal infections in neutropenic patients continues to be a major problem for the clinician. Treatment of such infections with amphotericin B is difficult, because of its many side-effects. In a neutropenic mouse model, itraconazole appeared to be as effective...

... in the right lung and left occipital region were observed on chest radiography and brain CT scanning, respectively. Aspergillus fumigatus was detected in lung and brain biopsy samples. Intravenous amphotericin B was started on 10 December 1988. During treatment, WBC rose progressively to more than 6 × 10 9 /l...

...K.P. Fu; D. Isaacson; B. Foleno; L. LoCoco The in vitro activity of saperconazole against eight candidal species (81 strains) was determined and compared with fluconazole, Sch 39304 and amphotericin B. Using brain heart infusion broth with an inoculum of 10 4 CFU/ml, the MIC ranges (μg/ml...

...H. Dermoumi 221 yeast strains including 131 of Candida albicans, 21 of C. tropicals, 23 of C. parapsilosis, 19 of C. glabrata, 7 of C. guilliermondii, 6 of C. krusei and of other species were isolated from the blood. The activity of fluconazole and amphotericin B was investigated by means...

... and 9 after infection, respectively. All animals presented invasion of almost all internal organs and skin eruptions developing into ulcers. Oral treatment with ketocon-azole, itraconazole, fluconazole or saperconazole was inefficacious. Parenteral treatment with amphotericin B prolonged survival...

...Annemarie Polak Combination pairs of 5-fluorocytosine (5-FC) + itraconazole (Itra), 5-FC + fluconazole (Flue), and amphotericin B (Amph B) + Itra were administered to mice with experimental candidiasis, cryptococcosis, aspergillosis and wangiellosis with a variety of combination ratios. The life...

...Dennis M. Dixon; Annemarie Polak Amphotericin B (Amph B), 5-fluorocytosine (5-FC), ketoconazole (KTZ), fluconazole (FLZ), amorolfine (AMOR) and terbinafine (TER) were tested against 3 agents of central nervous system phaeohyphomycosis in vitro and in life-threatening infections in mice. The fungi...

...Ethan Rubinstein The fungicidal effect of amphotericin B and 5-fluorocytosine (5-FC) on fungi incorporated into blood and fibrin clots was investigated. Amphotericin B was ineffective against fungi incorporated into blood clots, but effective in the eradication of fungi in fibrin clots. 5-FC...

...William H. Beggs; Fred A. Andrews; George A. Sarosi Amphotericin B (AMB)-5-fluorocytosine (5-FC) synergism has generally been observed in yeasts displaying 5-FC resistance. The present study was designed to assess activity of these drugs on yeasts showing susceptibility to 5-FC as well as AMB...

...Annemarie Polak; H.J. Scholer; M. Wall Combination pairs of the major systematic antimycotic drugs, amphotericin B (AmphB), 5-fluorocytosine (5-FC) and ketoconazole (Ktz) were administered to mice with experimental candidiasis, cryptococcosis and aspergillosis at a variety of combination ratios...