Background: The microinjection of penicillin in the medulla oblongata caused different alterations in the global respiratory output. The purpose of this paper was to study the involvement of impulse activity and the functional relationship of bulbar neurons in mechanisms underlying experimentally induced respiratory arrhythmias. Methods: Extracellular activity of neurons and diaphragmatic electromyogram activity were recorded and analyzed. Results: Penicillin microinjection increased the mean discharge rate of bulbar neurons and caused the prolongation of discharge of inspiratory neurons. Cross-correlation analysis revealed new excitatory connections between neurons and a high level of positive synchronization of neuronal activity. Conclusion: The local blockage of synaptic inhibition by penicillin within respiratory areas leads to drastic changes in the functioning of neuronal elements of the single respiratory network.

Keywords:
Medulla oblongata, Respiratory neurons, Penicillin microinjection
This content is only available via PDF.
© 2006 S. Karger AG, Basel
2006
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.