Background: Little is currently known regarding the cancer-preventive potential of cyanidin-3-O-β-glucopyranoside (Cy-g) apart from its antioxidant activity. Methods: We tested Cy-g on Jurkat and HL-60 leukemia cell lines and, to help elucidate whether the effects of Cy-g are specific for cancer cells, also on normal T lymphocytes. Results: Cy-g induced apoptosis in all three cell systems, and this indicated that Cy-g was not selective towards leukemia cells. Moreover, Cy-g caused HL-60 differentiation. The induction of apoptosis and cytodifferentiation involved different proteins, thus suggesting that Cy-g-induced apoptosis and cytodifferentiation are two distinct events. Conclusions: Although obtained in vitro, our findings indicate that Cy-g possesses some interesting biological properties that should encourage further investigation as regards its chemotherapeutic potential.

Keywords:
Cyanidin-3-O-β-glucopyranoside, Apoptosis, Cytodifferentiation, Jurkat cells, HL-60 cells, Lymphocytes, human
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© 2005 S. Karger AG, Basel
2005
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