The pharmacokinetics of ciprofloxacin were evaluated in 11 patients (3 patients with impaired renal function) with advanced liver cirrhosis after a single oral dose of 500 mg. Mean serum peaks were 2.80 ± 1.00 mg/l in 64 ± 37 min after intake in patients with normal renal function. Elimination was reduced in comparison with healthy volunteers: t½β510 ± 158 min with a total area under the curve of 18.2 ± 10.3 mg x h/1. Mean recovery of the parent compound from urine was 38 ± 9% of the dose. In 3 patients with cirrhosis plus poor renal function, elimination was markedly reduced. In patients under 60 years with good renal function, the standard dose does not require a reduction.

Keywords:
Pharmacokinetics, Ciprofloxacin, Liver, Cirrhosis
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© 1990 S. Karger AG, Basel
1990
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