The pharmacokinetics of bacampicillin, a prodrug of ampicillin which is absorbed from the gastrointestinal tract, were studied in 10 healthy male volunteers after administration of 1,200 mg in a single oral dose. The pharmacokinetic analysis was carried out by applying a single-compartment kinetic model with zero-order absorption. The apparent duration of absorption (T) was about 1 h for all subjects. The peak plasma concentrations (Cmax) were 17.89 ± 1.82 μ g/ml, and the mean plasma half-life during β-phase was 1.17 ± 0.14 h. The area under the curve was 41.22 ± 5.29 μ g . h/ml. The mean urinary recovery during 24 h amounted to 76.4 ± 3.65 % of the dose.

Keywords:
Bacampicillin, Pharmacokinetics, Zero-order absorption
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© 1988 S. Karger AG, Basel
1988
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