During recent decades there has been a controversial discussion if comparable plasma level profiles which are rather constant or those which show a high peak are more efficient for the cure of gonorrhoea. So far, investigations in this field were not based on the Grasso apparatus. Although the findings with cefotiam and ceftizoxime do not allow to formulate a general hypothesis without any restriction, it can be stated that on the basis of an identical area under the antibiotic level time curve, ‘peak concentration’ profiles are more favourable.

Keywords:
Neisseria gonorrhoeae, Cephalosporins, Therapy of gonorrhoea, Optimization of plasma level profiles
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© 1988 S. Karger AG, Basel
1988
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