In the diagnosis of classical systemic mycoses, as caused by Blastomyces dermatidis, Coccidioides immitis, Histoplasma capsulatum and Paracoccidioidesbrasiliensis, serodiagnostic procedures in conjunction with skin tests are of significant diagnostic and prognostic value. The diagnosis of aspergillus mycosis is facilitated greatly by serological tests and the same is true for recognition of cryptoeoccus mycosis by means of serological detection of the cryptococcal antigen. Great progress has also been made in the evaluation of Candida antibodies in patients’ sera.

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