Following oral administration of trimethoprim (TMP) in doses varying from 5.7 to 9.8 mg TMP per kg body weight per 24 h over a period of 1–22 days, the concentration was determined in normal and pathological lung Concentration tissue (obtained by open biopsy) in a total of 45 cases. A microbiological method was used to determine the concentration, using Bacillus pumilus as test organism. The concentration of TMP in lung tissue was found to be significantly higher than in serum. The increased concentration in macroscopically normal lung tissue varied from 1 to 8½ times the corresponding serum concentration (the median ratio = 3½), and was found to be independent of the magnitude of the dose administered, the duration of the administration and the pathological changes in the lung tissue when evaluated by histological examination. In lung tissue with a macroscopical appearance of inflammation or atelectasis, a significantly higher TMP concentration was found than in tissue with a normal appearance. The concentration of TMP varied from 2 to 12½ times the corresponding serum concentration (the median ratio = 5).

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.