... of heterozygosity Next-generation sequencing Precision medicine Cancer is a genomic disorder resulting from cellular accumulation of genomic alterations. These genomic alterations include: single-nucleotide variants (SNVs) leading to missense or nonsense amino acid change, or a splice site substitution...

... of this disease. Finally, certain environmental and psychological factors probably trigger the disease via epigenetic mechanisms. In this review, we summarize and discuss recent epigenetic studies of SLE and suggest a personalized approach to the dissection of disease onset and therapy or precision medicine. We...