.... Epigenetic regulation Pathogenesis Precision medicine Systemic lupus erythematosus Histone modification miRNA DNA methylation/demethylation Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with a diverse array of clinical manifestations [Fairhurst et al., 2006; Tsokos...

... demethylation. In fact, in addition to their role as methylcytosine dioxygenases, TET proteins are closely related to histone modification, interact with metabolic enzymes as well as other proteins, and cooperate in transcriptional regulation. In this review, we summarize the recent progress in this exciting...

...Shihan Yan; Qi Zhang; Yingnan Li; Yan Huang; Lin Zhao; Junjun Tan; Shibin He; Lijia Li Plant roots mainly consist of division, elongation and maturation regions. Histone modifications of chromatin play a vital role in plant cell growth and differentiation. However, there has been no systematic...

... histones. They are categorized into 4 groups, and a 4-layer model of the human metaphase chromosome has been developed. There are upper limits for DNA volume. In all plants examined to date the DNA volume does not exceed 3% of the nuclear volume. Histone modification also has an impact on the spatial...