...%; stage I-II: 23%; p = 0.012). Increasing expression of RAP1GAP after demethylation with 15 µM of 5-Aza was observed in both cell lines. These results indicate that DNA hypermethylation in CpG74 a can be considered as an epigenetic biomarker in DTC. [email protected] 11 11 2020 25 03...

... Coffin-Siris syndrome Epigenetics Monocytes NOMe-seq SWI/SNF For spatial reasons, about 2 metres of human genomic DNA are tightly wound around nucleosomes to fit in the approximately 10-µm cell nucleus. These nucleosomes do not only have a packaging role, but the nucleosome positioning also...

...Miloslava Fojtová; Jiří Fajkus As chromatin structures, telomeres undergo epigenetic regulation of their maintenance and function. In plants, these processes are likely of a higher complexity than in animals or yeasts, as exemplified by methylation of cytosines in plant telomeric DNA or reversible...

.... These can further regenerate homozygous plants for production of new isogenic lines, an important biotechnological tool for crop breeding. DNA methylation constitutes a prominent epigenetic modification of the chromatin fiber which regulates gene expression. Changes in DNA methylation accompany...

... are important biotechnological tools in plant breeding. Recent studies have revealed the involvement of DNA methylation in regulating this process, but no information is available on the role of histone modifications in microspore embryogenesis. Histone modifications are major epigenetic marks controlling gene...

... protein exchange at a genome-wide scale with consequences in chromatin structure and gene activity. Arabidopsis Cell cycle Chromatin DNA replication Epigenetics Gene expression Histone H3 Plant The first scientist who described and named histones was Albrecht Kossel, who isolated...

..., instructions or products referred to in the content or advertisements. Chromatin DNA damage repair Epigenetics Inhibitors Plants Eukaryotic genomes consist of DNA organized into chromosomes. DNA sequence and chromosome integrity are challenged by DNA replication errors and the occurrence...

... to unravel these threads and understand the complex genomic changes involved in each. We present here an overview of lessons learnt from studies of natural and artificial polyploids, and from comparisons between the 2, covering basic cellular and metabolic consequences through to alterations in epigenetic...

...V. Sgaramella Both theory and experimentation suggest that during development, the DNA of multicellular organisms, recognized as graced with a lifelong intrinsic stability, is instead target of several modifications (point mutations, larger structural variations, epigenetic marks) and partner...

...M. Mandrioli; P. Azzoni; G. Lombardo; G.C. Manicardi A detailed karyotype analysis of the oleander aphid Aphis nerii focusing on the distribution, molecular composition and epigenetic modifications of heterochromatin was done in order to better understand the structure and evolution of holocentric...

... is either a bit of both, depending on the tissue being studied, or still remains to be determined. The centromeres are the most dynamic and least well understood part of the nucleus, subject to rapid evolutionary change and with an epigenetic mark based on a special form of histone CENH3. Nonetheless...

.... Base excision repair Chromatin remodeling DNA damage response DNA repair Double-strand break Epigenetics Histone post-translational modifications Homologous recombination Non-homologous end-joining Nucleotide excision repair In the present work, we have addressed the best-known histone...

.... Allopolyploids Changes in genes Epigenetics F 1 hybrids Gene expression Genome balance When Karpechenko first produced fertile polyploid hybrids of Raphanus sativus L. × Brassica oleracea L. in 1928, he could not have realised how the science of hybridity and allopolyploids would progress to its...