Chromosomal analyses of several tissues of a bovine true hermaphrodite revealed a diploid XX/triploid XXY chimerism. This is believed to be the first report of an established triploid cell line in Bos taurus. Only XX diploid or near diploid cells were seen in the first 300 metaphases from cultured peripheral blood, but a single 88, XXY metaphase was found when an additional 400 metaphases were scored. Three diploid XXY cells, analogous to human Klinefelter cells, and 221 diploid or near diploid XX cells were seen in 224 bone-marrow metaphases. Only the diploid XX cell line was observed in 200 metaphases from a skin specimen. The triploid cell line would have gone undetected if only 200 metaphases per culture of blood, skin and bone marrow had been examined. This finding illustrates the ease with which chimerism can be overlooked in some extreme cases. The triploid cell line was present in the kidneys, right prefemoral lymph node, uterus and gonads. The incidence of triploid cells was significantly higher in mesodermal tissues of the right side homolateral to the ovotestis and significantly higher in the testicular portion of the ovotestis (P < 0.001).

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.